Individualized Versus Conventional Perioperative Blood Pressure Management

Launched by SEOUL NATIONAL UNIVERSITY HOSPITAL · Jan 24, 2024

Keywords

ClinConnect Summary

This clinical trial is studying two different ways to manage blood pressure during and after major non-cardiac surgeries. The goal is to see which method helps prevent serious complications, such as heart attacks, strokes, or kidney problems, after surgery. In this study, nearly 1,900 patients will be randomly assigned to one of two groups: one group will have their blood pressure managed based on their individual baseline levels, while the other group will follow a standard blood pressure target.

To be eligible for this trial, patients need to be 65 years or older, or at least 45 years old with certain heart or vascular conditions. They must be scheduled for non-cardiac surgery that lasts at least two hours and will be under general anesthesia. Participants will be monitored closely for any major health issues that arise within a week after their surgery or until they leave the hospital. This study is currently recruiting participants, and it's an important opportunity to help improve surgical care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged ≥65 or,
• • those aged ≥45 with a history of coronary artery disease, peripheral vascular disease, transient ischemic attack/stroke, or congestive heart failure,
• • undergoing non-cardiac surgery under general anesthesia with an anticipated duration of ≥2 hours.
• Exclusion Criteria:
• • Emergency surgery
• • Organ transplantation surgery
• • Brain/carotid artery surgery
• • American Society of Anesthesiologists physical status 5 or 6
• • Pregnancy
• • Uncontrolled preoperative hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg)
• • Estimated glomerular filtration rate \<30 ml/min/1.73m2
• • Renal replacement therapy
• • Acute decompensated heart failure
• • Sepsis
• • Shock
• • Use of inotropes/vasopressor infusion (dopamine, norepinephrine, vasopressin, etc.)