Postoperative Opioid and Respiratory Depression in Opioid Naive and Chronic Opioid Patients
Launched by RIGSHOSPITALET, DENMARK · Jan 17, 2024
Trial Information
Current as of May 18, 2025
Completed
Keywords
ClinConnect Summary
Aim: To describe the duration of desaturation and bradypnea in postoperative opioid-naïve and chronic opioid patients within the first four hours following opioid administration in addition to the chronic dose, using a continuously wireless monitoring system.
Patients: 691 patients included from two previous WARD (Wireless Assessment of Respiratory and circulatory Distress) projects. Continuous wireless monitoring data of peripheral tissue oxygenation (SpO2) and respiratory rate (RR) was conducted in postoperative patients. Data were stratified into opioid-naïve and chronic opioid patients...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients from studies WARD Surgery Observational \[gov: NCT03491137\]
- • The control group from WARD Surgery Randomized Controlled Trial \[gov: NCT04640415\]
- Exclusion Criteria:
- • Less than 30 minutes of continuous monitoring data within the 60-minute window prior to opioid administration
- • Less than 120 minutes (\<50% of theoretical maximum) of monitoring data available during the four-hour observation period
- • Patients who received transdermal fentanyl as postoperative opioid
- • Patients with a baseline saturation or respiratory rate below the prespecified thresholds
- • Patients with a BMI of ≥40 or diagnosed with COPD were excluded in the analysis of SpO2 \<92%
About Rigshospitalet, Denmark
Rigshospitalet, located in Copenhagen, Denmark, is one of the leading hospitals in Scandinavia and a prominent center for clinical research and innovation. As a key academic institution affiliated with the University of Copenhagen, Rigshospitalet is dedicated to advancing healthcare through rigorous clinical trials and groundbreaking research across various medical disciplines. The hospital’s commitment to excellence is reflected in its multidisciplinary approach, collaboration with international research networks, and focus on improving patient outcomes through evidence-based practices. With state-of-the-art facilities and a team of highly qualified professionals, Rigshospitalet plays a crucial role in translating scientific discoveries into effective treatments and therapies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Copenhagen, , Denmark
Copenhagen, , Denmark
Patients applied
Trial Officials
Eske Kvanner Aasvang, Professor
Study Chair
Rigshospitalet, Denmark
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported