Clinical Characteristics and Predictors of Adverse Outcomes in HFpEF

Launched by YA-WEI XU · Jan 18, 2024

Keywords

ClinConnect Summary

The prognosis for HFpEF is concerning, marked by significant mortality and frequent hospital readmissions. The exact mechanisms underlying HFpEF remain unresolved. The clinical syndrome arises from intricate interactions among various risk factors, leading to organ dysfunction and clinical symptoms. Common co-morbidities, including atrial fibrillation, diabetes, chronic kidney disease, and obesity, may influence HFpEF pathophysiology. Recent discussions suggest an inflammatory-metabolic phenotype in HFpEF, characterized by heightened inflammatory biomarkers, insulin resistance, hyperglycemi...

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Eligibility criteria

• Inclusion Criteria:
• • Patients diagnosed with HFpEF; Diagnostic criteria for HFpEF
• • Presence of heart failure signs/symptoms symptoms
• • Preserved left ventricular ejection fraction (EF) ≥50%
• • BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL;
• • At least one additional criteria: presence of cardiac functional and structural abnormalities or diastolic dysfunction.
• Exclusion Criteria:
• • LVEF lower than 50%
• • Patients with serious hepatic and renal failure,
• • Non-cardiac causes of dyspnea, such as, asthma
• • Primary pulmonary hypertension.
• • Severe valvular heart disease.
• • Pericardial disease.
• • Recent history of myocardial infarction.
• • Coronary artery disease (stenosis\>50).
• • Reduced contrast opacification (for caIMR assessment).