Ciprofol Versus Propofol for Anesthesia Induction in Cardiac Surgery: A Randomized Double-blind Controlled Clinical Trial

Launched by LE YU · Mar 10, 2024

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ClinConnect Summary

This clinical trial is studying a new medication called ciprofol, which is being compared to a commonly used anesthetic called propofol for patients undergoing heart surgery. Ciprofol is designed to work quickly, cause less discomfort during injection, and have a milder effect on the heart compared to propofol. The trial aims to understand how effective and safe ciprofol is for patients who need anesthesia during cardiac procedures.

To participate in this trial, individuals must be between the ages of 55 and 75 and scheduled for elective heart surgery, such as coronary artery bypass surgery or heart valve replacement. They should have a specific level of heart function, as classified by medical standards. However, those with certain health issues, like severe liver or kidney problems, or a history of allergies to certain medications, are not eligible. If you or a family member meet these criteria and are interested, this study may provide an opportunity to help advance medical knowledge about anesthesia in heart surgery. Participants can expect to receive careful monitoring throughout the trial to ensure their safety and well-being.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Elective surgery patients
• • 2. Aged 55 to 75
• • 3. New York Heart Association class II or III cardiac functions
• • 4. Median sternotomy approach for coronary artery bypass grafting or heart valve replacement procedures
• Exclusion Criteria:
• • 1. With a history of benzodiazepine allergy
• • 2. Significant liver or kidney insufficiency
• • 3. Coagulation dysfunction
• • 4. Neurological or psychiatric disorders
• • 5. Undergone major surgery within the past three months.