Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery

Launched by THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE · Mar 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a medication called oliceridine to see how well it works for managing moderate to severe pain after orthopedic surgery, which is surgery on bones and joints. The researchers want to find out if oliceridine is a safer and more effective option for pain relief compared to other treatments. Participants will be asked to rate their pain at different times and will receive varying doses of oliceridine to help the researchers understand how it works.

To participate in this trial, you need to be an adult who is scheduled for elective orthopedic surgery and can communicate your pain levels clearly. However, if you have certain health conditions, like severe obesity, advanced tumors, or other serious medical issues, you may not be eligible. If you join the trial, you will help contribute to important research that could improve pain management for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. elective orthopedic surgery under general anesthesia.
• • 2. The patient can communicate normally and has the correct expression of pain
• Exclusion Criteria:
• • 1. Patients with advanced tumor
• • 2. Other acute and chronic pain conditions are present
• • 3. Severely obese (30 kg/m2)
• • 4. Pregnant or lactating women
• • 5. Allergy to opioids
• • 6. Sleep apnea syndrome
• • 7. Long-term opioid treatment
• • 8. Patients with mental and nervous system diseases, gastrointestinal obstruction, chronic obstructive pulmonary disease or pulmonary heart disease, cardiovascular disease
• • 9. Abnormal liver function during screening
• • 10. Abnormal renal function during screening