Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury

Launched by ASSIUT UNIVERSITY · Mar 23, 2024

Keywords

ClinConnect Summary

Posttraumatic consequences are common causes of disability and long-term morbidity. Traumatic brain injuries (TBIs) are traditionally classified into primary and secondary injuries. Primary brain injury is usually mechanically induced and occurs at the moment of injury while secondary injury is not mechanically induced, delayed from the moment of injury and may superimpose a previously injured brain by mechanical forces. Primary brain injury may be associated with focal scalp injury, skull fractures, brain contusion caused by contact (i.e. an object striking the head or the brain striking t...

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Eligibility criteria

• Inclusion Criteria:
• • Adults (age: 18 - 60 years old)
• • History of primary traumatic closed head injury
• • At least 6 months after TBI
• • Mild/moderate previous TBI
• • Normal neuroimaging of the brain at the period of the study.
• Exclusion Criteria:
• • Secondary injury or superimpose injury on a brain already affected by a mechanical injury
• • patients with duration of illness less than 6 months
• • History of open or severe head injuries
• • Severe neurologic consequences after TBI
• • Post traumatic seizures
• • Posttraumatic hydrocephalus'
• • Posttraumatic abnormal neuroimaging of the brain
• • History of chronic mental or neurologic disorders (e.g. comorbid schizophrenia, severe manic phase of bipolar disorder or intellectual disability).
• • Substance abuse
• • Pregnancy
• • Individuals with the following physical conditions that are described in manufacturer's package including history of epilepsy or convulsion, renal dysfunction, factors increasing urine pH and severe liver dysfunction