Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke

Launched by THE FIRST HOSPITAL OF HEBEI MEDICAL UNIVERSITY · Mar 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how well a medication called pentoxifylline can help improve thinking and memory problems in people who have had an ischemic stroke, which is a type of stroke caused by a blockage in blood flow to the brain. Researchers believe that pentoxifylline might help by increasing blood flow and oxygen in the brain, which could protect the brain's nerve signals and enhance cognitive function. Participants will be divided into two groups: one will receive pentoxifylline in addition to standard stroke treatments, while the other group will receive standard treatments only.

To be eligible for this trial, participants must be Han Chinese adults aged 40 to 80 who are right-handed and have mild cognitive impairment, but no dementia. They should also have a specific score on a stroke severity scale and be able to perform daily activities independently. Participants can expect to undergo various tests, including brain scans, to monitor how well the medication works and to understand how it affects brain function. It's important to note that individuals with certain conditions or those taking specific medications that could affect cognitive function will not be able to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Han Chinese, age 40-80 years old, male and female, right-handed;
• • The diagnosis is consistent with the Expert Consensus on the Management of Cognitive Impairment after Stroke 2021;
• • NIHSS score 1-15 points;
• • Daily Living Ability Scale (ADL) ≥75 score;
• • The Informed consent signed by the patient or his legal representative
• Exclusion Criteria:
• • Can not cooperate with the examination (including neuropsychological tests and scale assessment);
• • There were memory disorders, dementia with lewy bodies and frontotemporal dementia before the onset of stroke events;
• • There were definite infectious diseases 2 weeks before admission; Have a serious mental illness, previous history of cancer, alcohol or drug abuse;
• • Use of drugs that may affect cognitive function, including sedatives, anti-anxiety drugs, hypnotics, nootropic drugs, and cholinoid drugs;
• • Can not accept brain MRI examination