Efficacy of Vonoprazan in Eradication of Resistant Strain of Helicobacter Pylori
Launched by AIN SHAMS UNIVERSITY · May 13, 2024
Trial Information
Current as of May 23, 2025
Completed
Keywords
ClinConnect Summary
This randomized controlled trial included two groups of Egyptian patients diagnosed with dyspepsia related to Clarithromycin-resistant strains of H.pylori.
* Group (1) included 160 patients received Vonoprazan 20 mg oral once daily + Levofloxacin 500 mg oral once daily + Amoxicillin 1 gm oral twice daily for two weeks.
* Group (2) included 160 patients received Pantoprazole 40 mg oral twice daily + Levofloxacin 500 mg oral once daily + Amoxicillin 1 gm oral twice daily for 14 days.
The included cases were collected from gastroenterology outpatient clinic and inpatient department at Ain sh...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • patients with dyspepsia related to Clarithromycin-resistant strains of H.pylori. All cases were diagnosed with H. Pylori resistant infection after clarithromycin based treatment regimen for H. pylori confirmed with persistent positive test of fecal H. pylori Ag before the starting of the study.
- • Must be able to swallow tablets.
- Exclusion Criteria:
- • Cases with drug allergy from drugs included in the study.
- • those having inflammatory-bowel diseases.
- • those with malabsorption syndrome.
- • those having gastroenterology malignancy.
- • patients on immunotherapy.
- • HIV patients.
About Ain Shams University
Ain Shams University, established in Cairo, Egypt, is a prestigious higher education institution renowned for its commitment to academic excellence and research innovation. As a clinical trial sponsor, the university leverages its extensive resources and expertise in various medical and scientific disciplines to advance healthcare through rigorous research initiatives. With a focus on ethical practices and adherence to regulatory standards, Ain Shams University aims to contribute to the development of new therapies and improve patient outcomes, fostering collaboration among researchers, healthcare professionals, and industry partners in the pursuit of medical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cairo, , Egypt
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported