Precise Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Bleeding: A Randomized Controlled Trial

Launched by NATIONAL CHENG-KUNG UNIVERSITY HOSPITAL · May 14, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help stop gastrointestinal bleeding, which is when there is bleeding in the digestive system. The researchers want to see if using two specific medications, tranexamic acid and sucralfate, right at the site of the bleed can help prevent it from happening again. This study will involve 60 patients who are experiencing gastrointestinal bleeding and are undergoing endoscopy, a procedure to look inside the body using a thin tube with a camera. Eligible participants must be at least 18 years old and have signs of bleeding, such as vomiting blood or having bloody stools. However, those who don’t need this procedure, have allergies to the medications, are pregnant, or have certain medical conditions will not be included.

If you or a loved one participates in this trial, you will first receive standard treatment to stop the bleeding. After that, the research team will carefully apply the two medications directly to the bleeding area. All participants will be monitored for the next 28 days to see if the bleeding comes back. This study is important because it aims to find better ways to reduce the chances of rebleeding, which can happen in many patients after treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Eligible participants include patients aged ≥ 18 years who accept endoscopy for GIB, including hematemesis, Tarry stool, or bloody stool
• Exclusion Criteria:
• • no need of endoscopic hemostasis
• • allergy to sucralfate, tranexamic acid, or barium
• • pregnancy
• • patients with hollow organ perforation