The Aim of This Study is to Determine if Oocyte Sorting for Group Culture Using an Artificial Intelligence Image Analysis Tool (MagentaTM) Increases the Usable Blastocyst Yield and Subsequent Pregnancy in Patients Undergoing IVF

Launched by OVATION FERTILITY · Jul 23, 2024

Keywords

ClinConnect Summary

This clinical trial is looking to see if a new technology called Magenta™, which uses artificial intelligence to analyze images of eggs (oocytes), can help improve the chances of successful pregnancies for patients undergoing in vitro fertilization (IVF). The goal is to find out if sorting these eggs based on their quality before they are used in the IVF process can lead to more usable embryos and higher pregnancy rates.

To be eligible for this study, participants need to have a specific type of mature eggs and be undergoing certain types of IVF procedures, such as using either their own or a donor's sperm. The trial is open to anyone who meets these criteria, but it excludes those with severe male infertility or other specific conditions. If you join the study, you will be part of a process that aims to improve IVF outcomes, and you'll be contributing to research that could help many others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Fresh MII oocytes
• • ICSI cycles with patient's or donor's sperm
• • Patient's or donor's oocytes
• • Full IVF cycle information available (including total number of oocytes retrieved, total MII oocytes, fertilization, embryo and blastocyst development, as well as ploidy status or implantation results, and 6-7 week ultrasound, if applicable)
• • Good quality images of MII oocytes taken with a specified camera (Basler) and Future Fertility Software
• • Single embryo transfers (SETs) at blastocyst stage.
• • Blastocyst freeze-all cycles
• Exclusion Criteria:
• • Severe male factor infertility (\<1 million motile), including surgically retrieved sperm.
• • ICSI cycles inseminating in vitro matured (IVM) oocytes
• • Rescue ICSI oocytes (oocytes failed standard IVF and are re-inseminated by ICSI)
• • Low quality images - Poor quality images on day of upload or before unblinding
• • Lack of correlating reproductive outcomes (full IVF lab results not available).
• • Autologous or donor frozen/warmed oocytes
• • Day 3 embryo transfers or cleavage stage embryo freezing
• • Patients with less than 6 mature oocytes