Exparel Versus Bupivacaine in Post-operative Pain Control

Launched by CASE WESTERN RESERVE UNIVERSITY · Aug 7, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of two types of pain relief medications—Exparel (which is a special form of bupivacaine) and standard bupivacaine—used after surgery to remove wisdom teeth (also known as third molars). The goal is to see how well these medications control pain after the surgery and how much additional pain medication patients might need afterwards.

To participate in this study, you must be an adult aged 18 or older, scheduled for the removal of all four wisdom teeth, and in good health according to specific medical guidelines. Unfortunately, if you have allergies to certain pain medications, are pregnant, or have certain medical conditions, you may not be eligible. If you join the study, you will receive one of the two pain relief medications, and researchers will monitor your pain levels and any additional medications you might need after your surgery. This could help improve pain management for future patients undergoing similar procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male and nonpregnant female adults (≥18 years of age) with American Society of Anesthesiologists physical status classification 1, 2, or 3 who were scheduled to undergo bilateral third molar extraction (extraction of all 4 third molars) under local anesthesia and general anesthesia Study participants were required to have full or partial bony impaction of both mandibular third molars.
• Exclusion Criteria:
• • history of allergy or contraindication to amide-type local anesthetics, epinephrine, or opioids a history of any disease or condition or recent use of any drug that, in the opinion of the investigator, might increase the risk of surgery or interfere with study evaluations any use of long-acting opioids, nonsteroidal anti-inflammatory drugs, aspirin, or acetaminophen within 3 days before screening or use of opioids within 24 hours of screening Patient that is pregnant or suspected to be pregnant Adults that cannot speak English, adults that are unable to consent on their own, or persons that are listed as vulnerable individuals will not be part of the study