Clinical Study of Toothpaste Containing Zinc Lactate as Compared to Colgate Cavity Protection Toothpaste.

Launched by COLGATE PALMOLIVE · Aug 19, 2024

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Eligibility criteria

• Inclusion Criteria:
• • Subjects, ages 18-70, inclusive.
• • Availability for the six-month duration of the clinical research study.
• • Good general health.
• • Minimum of 20 uncrowned permanent natural teeth (excluding third molars).
• • Initial gingivitis index of at least 1.0 as determined by the use of the Loe and Silness Gingival Index.
• • Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification).
• • Signed Informed Consent Form
• Exclusion Criteria:
• • Presence of orthodontic bands.
• • Presence of partial removable dentures.
• • Tumor(s) of the soft or hard tissues of the oral cavity.
• • Advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone).
• • Five or more carious lesions requiring immediate restorative treatment.
• • Antibiotic use any time during the one-month period prior to entry into the study.
• • Participation in any other clinical study or test panel within the one month prior to entry into the study.
• • Dental prophylaxis during the past two weeks prior to baseline examinations.
• • History of allergies to oral care/personal care consumer products or their ingredients.
• • On any prescription medicines that might interfere with the study outcome.
• • An existing medical condition that prohibits eating or drinking for periods up to 4 hours.
• • History of alcohol or drug abuse.
• • Pregnant or lactating subjects.