MicroRNA Profile As a Biomarker of Liver Damage in Different Types of Liver Donors.
Launched by MAR DALMAU · Sep 23, 2024
Trial Information
Current as of April 02, 2025
Completed
Keywords
ClinConnect Summary
Between October 2019 and May 2021, perfusates, liver biopsies and serum samples were collected prospectively from adult deceased organ donors in Vall d\'Hebron University Hospital, Barcelona, Spain.
Samples from adult human brain death donors (n=10) and donors after circulatory death (n=10) were analyzed for the presence of miR-122, miR-148, miR-155, miR-22, miR-222 and ratio miR122/miR222, target biomarkers of liver injury selected from the literature.
To set the reference miRNA profiles, a subgroup of donors with unusable grafts due to significant steatosis (n=3) were analyzed.
Don...
Gender
ALL
Eligibility criteria
- I) Main donor groups (DBD and DCD):
- Inclusion Criteria:
- • Adult deceased liver donors
- Exclusion Criteria:
- • Pediatric donors (less than18 year-old)
- • Donors for re-transplantation cases
- • Donors who underwent split or partition liver technique to obtain two small grafts for two recipients (adult and pediatric).
- II) Discarded DBD grafts:
- Inclusion Criteria:
- • - Unusable grafts for transplantation due to moderate (30% to 60%) or severe (more than 60%) steatosis in liver biopsies.
- Exclusion Criteria:
- • Unusable grafts discarded for other reasons.
- • Pediatric donors (less than18 year-old)
- • Donors for re-transplantation cases
- • Donors who underwent split or partition liver technique to obtain two small grafts for two recipients (adult and pediatric).
- III) Control group:
- Inclusion criteria:
- • - Same inclusion criteria as the living liver donor program in our center: 18 to 60 years old, normal liver function, ultrasound without signs of liver disease and steatosis less than 30%.
- Exclusion criteria:
- • - Patients with preoperative deranged liver function tests.
Trial Officials
Ramon Charco, MD, PhD
Study Director
Chief of HPB surgery and Transplant Department in Vall d Hebron University Hospital
Concepción Gómez-Gavara, MD, PhD
Study Director
HPB surgery and Liver Transplant consultant in Vall d Hebron University Hospital
About Mar Dalmau
Mar Dalmau is a clinical trial sponsor dedicated to advancing medical research and innovation through the development of novel therapies. With a focus on enhancing patient outcomes, the organization collaborates with leading research institutions and healthcare professionals to conduct rigorous clinical trials across various therapeutic areas. Mar Dalmau is committed to maintaining the highest ethical standards and regulatory compliance, ensuring that all studies prioritize participant safety and scientific integrity. Through its strategic partnerships and patient-centric approach, Mar Dalmau aims to contribute significantly to the advancement of healthcare solutions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Barcelona, , Spain
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported