SAD and MAD Study of FTX-101 in Healthy Male Subjects

Launched by FIND THERAPEUTICS · Sep 25, 2024

Nctid: NCT06617546

Payload: {"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-10-04"}}, "protocolSection"=>{"designModule"=>{"phases"=>["PHASE1"], "studyType"=>"INTERVENTIONAL", "designInfo"=>{"allocation"=>"RANDOMIZED", "maskingInfo"=>{"masking"=>"QUADRUPLE", "whoMasked"=>["PARTICIPANT", "CARE_PROVIDER", "INVESTIGATOR", "OUTCOMES_ASSESSOR"]}, "primaryPurpose"=>"BASIC_SCIENCE", "interventionModel"=>"SEQUENTIAL"}, "enrollmentInfo"=>{"type"=>"ESTIMATED", "count"=>80}}, "statusModule"=>{"overallStatus"=>"RECRUITING", "startDateStruct"=>{"date"=>"2024-10", "type"=>"ESTIMATED"}, "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"2024-09", "completionDateStruct"=>{"date"=>"2025-06", "type"=>"ESTIMATED"}, "lastUpdateSubmitDate"=>"2024-09-25", "studyFirstSubmitDate"=>"2024-09-25", "studyFirstSubmitQcDate"=>"2024-09-25", "lastUpdatePostDateStruct"=>{"date"=>"2024-09-27", "type"=>"ACTUAL"}, "studyFirstPostDateStruct"=>{"date"=>"2024-09-27", "type"=>"ACTUAL"}, "primaryCompletionDateStruct"=>{"date"=>"2025-06", "type"=>"ESTIMATED"}}, "outcomesModule"=>{"primaryOutcomes"=>[{"measure"=>"Frequency of adverse events", "timeFrame"=>"Part A (SAD): Days -1-15; Part A (BA): Days -1-29; Part B (MAD): Days -1-28", "description"=>"Frequency of AE will be collected through AE monitoring."}, {"measure"=>"Severity of adverse events", "timeFrame"=>"Part A (SAD): Days -1-15; Part A (BA): Days -1-29; Part B (MAD): Days -1-28", "description"=>"Severity of AE will be collected through AE monitoring. AEs will be graded per the current National Cancer Institute's Common Terminology Criteria for Adverse Events."}, {"measure"=>"Number of patients with a change in general biochemistry, hematology, coagulation and urinalysis clinical laboratory parameters", "timeFrame"=>"Part A (SAD): Days -1, 4 and 15; Part A (BA): Days -1, 4, 14, 18, 29; Part B (MAD): Days -1, 5, 9, 13, 17, 28", "description"=>"Frequency of abnormal general biochemistry, hematology, coagulation, and urinalysis clinical laboratory values."}, {"measure"=>"Number of patients with a change in vital signs", "timeFrame"=>"Part A (SAD): Days -1-4 and 15; Part A (BA): Days -1-4, 14-18, 29; Part B (MAD): Days -1-17 and 28", "description"=>"Frequency of abnormal vital sign measurements."}, {"measure"=>"Number of patients with a change in 12-lead safety electrocardiogram (ECG)", "timeFrame"=>"Part A (SAD): Days -1-2, and 15; Part A (BA): Days -1-2, 14-16, 29; Part B (MAD): Days -1, 1, 3, 5, 7, 9, 11, 14, 28", "description"=>"Frequency of abnormal 12-lead ECG parameters including PR, RR, QRS, QT and QTcF."}, {"measure"=>"Number of patients with a change in physical examination findings", "timeFrame"=>"Part A (SAD): Days -1-4, and 15; Part A (BA): -1-4, 14-18, 29; Part B (MAD): Days -1-17, 28", "description"=>"Frequency of abnormal physical examination findings."}, {"measure"=>"Number of patients with a change in neurological examination findings", "timeFrame"=>"Part A (SAD): Days 1, 2, 4, and 15; Part A (BA): Days 1, 2, 4, 15, 16, 18, and 29; Part B (MAD): Days 1, 2, 5, 9, 14, 15, 17, and 29", "description"=>"Frequency of abnormal neurological examination findings."}, {"measure"=>"Frequency of injection site reactions", "timeFrame"=>"Part A (SAD): Days 1, 2, and 15; Part A (BA): Days 1, 2, 15, 16, and 29; Part B (MAD): Days 1-14, and 28", "description"=>"Evaluation of pain, tenderness, erythema/redness, swelling/induration or itching at the injection site will be rated mild (Grade 1), moderate (Grade 2), Severe (Grade 3), or potentially life-threatening (Grade 4)"}, {"measure"=>"Change in Columbia Suicide Severity Rating Scale (C-SSRS) score", "timeFrame"=>"Part A (SAD): Days -1-4, and 15; Part A (BA): Days -1-4, 14-18, and 29; Part B (MAD:) Days -1-17, and 28", "description"=>"Frequency of positive results for suicidality. The C-SSRS is a questionnaire designed for the assessment of suicidal ideation and behavior in adolescents and adults."}], "secondaryOutcomes"=>[{"measure"=>"Plasma Cmax", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, 15-18; Part B (MAD): Days 1-2", "description"=>"Peak or maximum observed concentration"}, {"measure"=>"Plasma Tmax", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, and 15-18; Part B (MAD): Days 1-2", "description"=>"Time of maximum observed concentration. If the maximum observed concentration is not unique, then the first maximum is used"}, {"measure"=>"Plasma AUC0-last", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, and 15-18; Part B (MAD): Days 1-2", "description"=>"Area under the concentration-time curve from dosing to the time of last quantifiable concentration (Tlast)"}, {"measure"=>"Plasma AUC0-∞ (Part A)", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, and 15-18", "description"=>"Area under the concentration time curve extrapolated to infinity, calculated as AUClast + Clast/λZ, where Clast is the last quantifiable concentration at time Tlast"}, {"measure"=>"Plasma AUC0-last/∞ (Part A)", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, and 15-18", "description"=>"Relative percentage of AUC0-last with respect to AUC0-∞"}, {"measure"=>"Plasma λz", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, and 15-18; Part B (MAD): Day 14-17", "description"=>"Apparent elimination rate constant, estimated by linear regression of the terminal linear portion of the log concentration versus the time curve"}, {"measure"=>"Plasma CL/F (Part A)", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, and 15-18", "description"=>"Apparent clearance, calculated as Dose/AUC0-∞"}, {"measure"=>"Plasma Vz/F (Part A)", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, and 15-18", "description"=>"Apparent volume of distribution, calculated as Dose/ λZ \\* AUC0-∞"}, {"measure"=>"Plasma Thalf (Part A)", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4, and 15-18", "description"=>"Terminal elimination half-life, calculated as ln (2)/λZ"}, {"measure"=>"Absolute bioavailability of FTX-101 [Part A (BA)]", "timeFrame"=>"Days 1-4, and 15-18", "description"=>"AUCsc and AUCiv will be assessed to determine the absolute bioavailability. Area under the first moment curve (AUMC0-last and AUMC∞) may also be calculated, as appropriate."}, {"measure"=>"Plasma AUC0-24 (Part B MAD)", "timeFrame"=>"Days 1-2", "description"=>"Area under the concentration-time curve over the dosing interval"}, {"measure"=>"Plasma Ctrough (Part B MAD)", "timeFrame"=>"Days 11 to 13", "description"=>"Plasma trough observed concentrations, for Day 11 to Day 13"}, {"measure"=>"Plasma Cmin,ss (Part B MAD)", "timeFrame"=>"Days 14-17", "description"=>"Minimum observed concentration at steady state"}, {"measure"=>"Plasma Cmax,ss (Part B MAD)", "timeFrame"=>"Days 14-17", "description"=>"Peak or maximum observed concentration at steady state"}, {"measure"=>"Plasma AUC0-τ (Part B MAD)", "timeFrame"=>"Days 14-17", "description"=>"Area under the concentration-time curve over the dosing interval"}, {"measure"=>"Plasma Tmax,ss (Part B MAD)", "timeFrame"=>"Days 14-17", "description"=>"Time of maximum observed concentration at steady state"}, {"measure"=>"Plasma Thalf (Part B MAD)", "timeFrame"=>"Days 14-17", "description"=>"Terminal elimination half-life, calculated as ln(2)/λZ"}, {"measure"=>"Plasma Cav (Part B MAD)", "timeFrame"=>"Days 14-17", "description"=>"Average steady-state plasma drug concentration calculated as AUC0-τ/τ"}, {"measure"=>"Plasma Fluctuation (Part B MAD)", "timeFrame"=>"Days 14-17", "description"=>"The range of steady-state concentrations divided by the average concentration (Day 14 only)"}, {"measure"=>"Plasma Swing (Part B MAD)", "timeFrame"=>"Days 14-17", "description"=>"Degree of swing over a dosing interval, after the last dose of a multiple-dose regimen expressed as a percentage. Calculated as 100\\*(Cmax-Cmin/Cmin)."}, {"measure"=>"Plasma Rac(Cmax) (Part B MAD)", "timeFrame"=>"Days 1-2, and 14-17", "description"=>"Accumulation ratio evaluated by comparing Day 14 Cmax,ss to Day 1 Cmax"}, {"measure"=>"Plasma Rac(AUC) (Part B MAD)", "timeFrame"=>"Days 1-2, and 14-17", "description"=>"Accumulation ratio evaluated by comparing Day 14 AUC0-τ to Day 1 AUC0-24"}, {"measure"=>"Urine Ae(0-last)", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4; Part B (MAD): Days 1, 2, and 14-17", "description"=>"Cumulative amount excreted over all time intervals (0 to Tlast), calculated as the sum of all amounts excreted from each interval (t1-t2)"}, {"measure"=>"Urine fe", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4; Part B (MAD): Days 1, 2, and 14-17", "description"=>"Fraction of unchanged drug excreted in urine during the time interval (expressed in %, calculated)"}, {"measure"=>"Urine CLR", "timeFrame"=>"Part A (SAD): Days 1-4; Part A (BA): Days 1-4; Part B (MAD): Days 1, 2, and 14-17", "description"=>"Renal Clearance (Ae(0-last)/ AUC0-last)"}]}, "oversightModule"=>{"isUsExport"=>false, "oversightHasDmc"=>true, "isFdaRegulatedDrug"=>true, "isFdaRegulatedDevice"=>false}, "conditionsModule"=>{"keywords"=>["remyelination", "myelin", "plexin A1", "neuropilin 1"], "conditions"=>["Healthy Volunteers"]}, "descriptionModule"=>{"briefSummary"=>"This is a Phase 1, first-in-human (FIH), single-center, randomized, double-blind, placebo-controlled study in healthy male subjects. The study will include the following 2 parts:\n\n* Part A: Single Ascending Dose (SAD) with a nested absolute bioavailability cohort in healthy male subjects\n* Part B: Multiple Ascending Dose (MAD) in healthy male subjects", "detailedDescription"=>"Study Rationale:\n\nFTX-101 is a first-in-class, synthetic peptide with a novel mechanism of action designed to promote the self-repair of myelin. FTX-101 is a highly selective modulator of the PlexinA1/Neuropilin 1 receptor system and displays no significant activity on any other target. FTX-101 interferes with the heterodimerization of the coreceptor system and, ultimately, with the activation of second messenger signaling pathways shown to inhibit both the differentiation and migration of oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs). Through this mechanism, FTX-101 disinhibits both the differentiation of OPCs to OLs and migration of OPCs into lesions, favorably promoting the remyelination process. The study is designed to evaluate the safety, tolerability and pharmacokinetic profile of single ascending doses and multiple ascending doses of FTX-101 subcutaneous injection and intravenous infusion in healthy male subjects. The study will characterize the pharmacokinetics of FTX-101 following SAD and MAD SC injection and IV infusion of FTX-101, and determine the absolute bioavailability of FTX-101 following SC injection relative to IV infusion. The study will also evaluate the immunogenic potential of FTX-101 and will also explore the relationship between FTX-101 concentration and the change from baseline corrected QT interval.\n\nDetailed Description:\n\nThis is a Phase 1, first-in-human (FIH), single-center, randomized, double-blind, placebo-controlled study in healthy male subjects. The study will include the following 2 parts:\n\n* Part A: SAD with a nested absolute bioavailability cohort in healthy male subjects\n* Part B: MAD in healthy male subjects\n\nPart A - SAD with a nested absolute bioavailability cohort:\n\nPart A consists of 5 planned cohorts (A1 to A5) of 8 healthy adult male subjects each. An additional SAD intermediate (lower) or equivalent dose cohort (A6) of 8 male subjects may be added at the discretion of the Sponsor. In each cohort, subjects will be randomized to receive a single subcutaneous (SC) dose (as 1 or 2 injection\\[s\\]) of either FTX-101 or placebo in a 3:1 (FTX-101: placebo) ratio to have a total of 6 subjects receiving FTX-101 and 2 subjects receiving placebo. An absolute bioavailability assessment will be integrated into one of the SAD cohorts (Cohort A2, Cohort A3 or Cohort A4). The absolute bioavailability cohort will receive an IV dose of the assigned study treatment in Period 2. The selection of the SAD cohort and dose level for absolute bioavailability assessment will be determined based on interim safety, tolerability, and available PK data of previous cohort(s).\n\nPart B - MAD:\n\nPart B consists of 3 planned cohorts (B1 to B3) of 8 healthy adult male subjects each. An additional MAD cohort (B4) of 8 male subjects may be added at the discretion of the Sponsor depending on emerging safety and plasma PK data from the previous cohort(s). The proposed dosing regimen (dose level and frequency) for the first cohort (B1) in Part B (MAD) will be based on available safety, tolerability, and PK data from Part A (SAD). The dosing regimens for each subsequent cohort in Part B will be determined based on the available blinded safety, tolerability, and PK data from Part A and any previous cohorts in Part B. In each cohort, subjects will be randomized to receive multiple SC doses of either FTX-101 or placebo in a 3:1 (FTX-101: placebo) ratio to have a total of 6 subjects receiving FTX-101 and 2 subjects receiving placebo."}, "eligibilityModule"=>{"sex"=>"MALE", "stdAges"=>["ADULT"], "maximumAge"=>"59 years", "minimumAge"=>"18 years", "healthyVolunteers"=>true, "eligibilityCriteria"=>"Key Inclusion Criteria:\n\n* Willingness to comply with all study procedures and availability for the duration of the study\n* Healthy adult male\n* Aged at least 18 years but not older than 59 years\n* Body mass index (BMI) within 18.5 kg/m\\^2 to 32.0 kg/m\\^2, inclusively\n* Non- or ex-smoker\n* Have no clinically significant diseases captured in the medical history or evidence of clinically significant findings on the physical examination (including vital signs) and/or ECG.\n\nKey Exclusion Criteria:\n\n* Supine or semi-supine pulse rate less than 45 beats per minute (bpm) or more than 100 bpm\n* Supine or semi-supine blood pressure below 90/50 mmHg\n* Supine or semi-supine blood pressure higher than 140/90 mmHg\n* History of significant hypersensitivity to FTX-101 or any related products (including excipients of the formulations) as well as severe hypersensitivity reactions (like angioedema) to any drugs\n* Presence or history of significant gastrointestinal, liver or kidney disease, or surgery that may affect drug bioavailability\n* History of significant cardiovascular, pulmonary, hematologic, neurological, psychiatric, endocrine, immunologic or dermatologic disease\n* Showing suicidal tendency from 6 months prior to screening\n* Presence of out-of-range cardiac intervals at screening defined as:\n\n * PR \\< 110 msec, PR \\> 200 msec\n * QRS \\< 60 msec, QRS \\>110 msec)\n * QT Interval Corrected for Heart Rate using Fridericia's Correction Formula (QTcF): • \\> 450 msec\n * History of additional risk factors for torsade's de pointes\n * Use of concomitant medications that prolong the QT/ corrected QT (QTc) interval\n* Current use (in the last 6 months) of alcohol (\\> 3 units of alcohol per day, intake of excessive alcohol, acute or chronic)\n* Any history of substance or alcohol use disorder within the past 2 years and/or current maintenance therapy (within the past 2 years) for treatment of substance use disorder\n* Use of any prescription drugs in the 28 days or 5 half-lives, whichever is longer, prior to the first study treatment administration, that in the opinion of an investigator would put into question the status of the participant as healthy\n* Use of St. John's wort in the 28 days prior to the first study treatment administration\n* Positive screening results to HIV Ag/Ab combo, hepatitis B surface Ag or hepatitis C virus tests\n* Intake of an investigational product (IP) in the 28 days prior to the first study treatment administration or within 5 times the elimination half-life of the IP, whichever is longer\n* Donation of plasma in the 7 days prior to the first study treatment administration\n* Donation of 1 unit of blood to American Red Cross or equivalent organization or donation of over 500 mL of blood in the 56 days prior to the first study treatment administration"}, "identificationModule"=>{"nctId"=>"NCT06617546", "briefTitle"=>"SAD and MAD Study of FTX-101 in Healthy Male Subjects", "organization"=>{"class"=>"INDUSTRY", "fullName"=>"Find Therapeutics"}, "officialTitle"=>"A Randomized, Double-Blind, Placebo-Controlled, First-in-Human, Nested Bioavailability Study to Assess Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Single and Multiple Ascending Doses of FTX-101 After Subcutaneous Injection of FTX-101 in Healthy Male Subjects", "orgStudyIdInfo"=>{"id"=>"FTX0101"}}, "armsInterventionsModule"=>{"armGroups"=>[{"type"=>"EXPERIMENTAL", "label"=>"Part A (SAD): Cohort A1", "description"=>"Single dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo in a 3:1 ratio", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part A (SAD): Cohort A2", "description"=>"Single dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo in a 3:1 ratio\n\nThis Cohort may include a nested Absolute Bioavailability Cohort. After the SC dose, there will be a 14-day washout period and a single intravenous infusion of FTX-101 or placebo will be administered.", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part A (SAD): Cohort A3", "description"=>"Single dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo in a 3:1 ratio\n\nThis Cohort may include a nested Absolute Bioavailability Cohort. After the SC dose, there will be a 14-day washout period and a single intravenous infusion of FTX-101 or placebo will be administered.", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part A (SAD): Cohort A4", "description"=>"Single dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo in a 3:1 ratio\n\nThis Cohort may include a nested Absolute Bioavailability Cohort. After the SC dose, there will be a 14-day washout period and a single intravenous infusion of FTX-101 or placebo will be administered.", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part A (SAD): Cohort A5", "description"=>"Single dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo in a 3:1 ratio", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part A (SAD): Cohort A6", "description"=>"Optional cohort to receive additional single ascending intermediate (lower) or equivalent dose of FTX-101 or placebo in a 3:1 ratio via SC injection", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part B (MAD): Cohort B1", "description"=>"Once daily dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo for 14 days in a 3:1 ratio", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part B (MAD): Cohort B2", "description"=>"Once daily dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo for 14 days in a 3:1 ratio", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part B (MAD): Cohort B3", "description"=>"Once daily dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo for 14 days in a 3:1 ratio", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}, {"type"=>"EXPERIMENTAL", "label"=>"Part B (MAD): Cohort B4", "description"=>"Optional cohort to receive once daily dose (as 1 or 2 SC injection\\[s\\]) of FTX-101 or placebo for 14 days in a 3:1 ratio", "interventionNames"=>["Drug: FTX-101", "Drug: Placebo"]}], "interventions"=>[{"name"=>"FTX-101", "type"=>"DRUG", "description"=>"Lyophilized powder for subcutaneous or intravenous injection", "armGroupLabels"=>["Part A (SAD): Cohort A1", "Part A (SAD): Cohort A2", "Part A (SAD): Cohort A3", "Part A (SAD): Cohort A4", "Part A (SAD): Cohort A5", "Part A (SAD): Cohort A6", "Part B (MAD): Cohort B1", "Part B (MAD): Cohort B2", "Part B (MAD): Cohort B3", "Part B (MAD): Cohort B4"]}, {"name"=>"Placebo", "type"=>"DRUG", "description"=>"Lyophilized powder for subcutaneous or intravenous injection", "armGroupLabels"=>["Part A (SAD): Cohort A1", "Part A (SAD): Cohort A2", "Part A (SAD): Cohort A3", "Part A (SAD): Cohort A4", "Part A (SAD): Cohort A5", "Part A (SAD): Cohort A6", "Part B (MAD): Cohort B1", "Part B (MAD): Cohort B2", "Part B (MAD): Cohort B3", "Part B (MAD): Cohort B4"]}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"66212", "city"=>"Overland park", "state"=>"Kansas", "status"=>"RECRUITING", "country"=>"United States", "facility"=>"Altasciences Clinical Kansas, Inc.", "geoPoint"=>{"lat"=>38.98223, "lon"=>-94.67079}}], "centralContacts"=>[{"name"=>"Robert L. Glanzman, MD, FAAN", "role"=>"CONTACT", "email"=>"rglanzman@findtherapeutics.com", "phone"=>"(415) 535 9032"}, {"name"=>"Violetta Dimitriadou, PhD", "role"=>"CONTACT", "email"=>"violettadimitriadou@findtherapeutics.com"}], "overallOfficials"=>[{"name"=>"Martin K. Kankam, MD, PhD, MPH, FAPCR", "role"=>"PRINCIPAL_INVESTIGATOR", "affiliation"=>"Altasciences Clinical Kansas, Inc."}]}, "ipdSharingStatementModule"=>{"ipdSharing"=>"NO"}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"Find Therapeutics", "class"=>"INDUSTRY"}, "responsibleParty"=>{"type"=>"SPONSOR"}}}}