Greater Houston Area Pediatric Bipolar Registry

Launched by THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER, HOUSTON · Oct 28, 2024

Keywords

ClinConnect Summary

The Greater Houston Area Pediatric Bipolar Registry is a research study aimed at understanding pediatric bipolar disorder in children and teenagers. The study will include kids and teens who have been diagnosed with bipolar disorder, those who have a parent with bipolar disorder, and healthy children without any psychiatric conditions. Researchers will collect blood and saliva samples to look for specific biological markers and genetic information related to bipolar disorder. They will also use brain imaging techniques, called MRI, to study how the brains of these children may be affected by mood and behavior issues.

To participate, children and teens aged 2 to 18 may qualify if they meet certain criteria, such as having a current mood disorder or being the child of a parent with bipolar disorder. However, those with certain conditions like autism, severe neurological disorders, or specific psychiatric diagnoses will not be eligible. Participants can expect to provide samples and undergo brain scans, and they will receive information about other research opportunities they may qualify for. This study aims to improve early identification and understanding of bipolar disorder in young people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for bipolar patients or offspring of bipolar parents:
• • Any current mood state (in the case of bipolar subjects)
• • For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
• • For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult
• Exclusion Criteria for bipolar patients or offspring of bipolar parents:
• • Autism Spectrum Disorder (ASD)
• • Developmental Intellectual Disorder
• • Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
• • Schizophrenia
• • Uncontrolled or severe medical problem per investigator judgment
• • For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability
• Exclusion Criteria for healthy control subjects:
• • Any Psychiatric Diagnosis
• • Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative
• • Any family history of a neurological condition in a first-degree relative.
• • Mental Retardation/Intellectual Disability
• • Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
• • Schizophrenia
• • Uncontrolled or severe medical problem per investigator judgement
• Exclusion criteria for annual visits:
• • Autism Spectrum Disorders (ASD)
• • Intellectual Developmental Disorder
• • Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
• • Schizophrenia
• • Uncontrolled or severe medical problem per investigator judgement

Trial Officials