Optimizing Transcranial Magnetic Stimulation for Stimulant Use Disorder

Launched by UNIVERSITY OF MINNESOTA · Jan 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called Transcranial Magnetic Stimulation (TMS) to help adults with stimulant use disorder, which is a condition where people struggle with using stimulants like cocaine. The trial aims to see how different ways of applying TMS can affect brain activity and behavior in participants who have been in treatment and are sober for at least two weeks. The researchers will also include some healthy individuals for comparison.

To participate, you need to be 18 years or older and able to provide consent. You should have a primary diagnosis of stimulant use disorder and have been sober for at least two weeks. Participants will undergo brain scans and have their brain activity recorded while receiving TMS in different ways during two visits to the lab. The study will involve some assessments before and after the TMS sessions to see how effective the treatment is. It’s important to note that there are some health conditions that may exclude you from participating, such as certain brain or medical issues. This trial is currently recruiting, and your participation could help improve treatments for stimulant use disorder.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 or older
• • Ability to provide consent and comply with all study procedures.
• • Meets Diagnostic and Statistical Manual of Mental Disorders criteria for StUD (As assessed by MINI and self-report; Participants may have current comorbid drug use, but primary diagnosis must be StUD; does not apply to healthy control participants).
• • At least 2 weeks of abstinence from substance use (other than caffeine or nicotine).
• • Intention to remain in an addiction treatment program until intervention completion (does not apply to healthy control participants).
• • Confident level of English language proficiency.
• Exclusion Criteria:
• • Any organic brain disorder (e.g. TBI, stroke).
• • Head injury resulting in skull fracture or loss of consciousness exceeding 30 minutes.
• • TMS contraindication (history of seizures, metallic cranial plates/screws or implanted device).
• • MRI contraindications (unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, claustrophobia).
• • Any psychotic disorder (Participants with other treated and stable psychiatric disorders will be included).
• • Presence of a condition that would render study measures impossible to administer or interpret.
• • Primary current substance use disorder diagnosis on a substance other than stimulants or cocaine, except for caffeine or nicotine.
• • Greater than 9 months abstinence from substance use (does not apply to healthy control participants).
• • Pregnancy or breastfeeding.

Trial Officials