Brain Functional Changes Accompany Modulatory Effects of Transcranial Direct Current Stimulation in Cognitive Impairment

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES, INDIA · Mar 3, 2025

Keywords

ClinConnect Summary

As apriori registration was not done before the initiation of the study and all the participants already underwent tDCS intervention, the investigators are herewith submitting the protocol of the study retrospectively following the completion of the project. This study was conducted at the National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India, with the approval of the NIMHANS Institutional Ethics Committee.

Study Sample: All consenting participants of both sexes (age range: 55 - 84 years) meeting the inclusion and exclusion criteria (see below), who consecutivel...

Gender

ALL

Eligibility criteria

• • Patients with Mild Cognitive Impairment and mild Alzheimer's Disease
• Inclusion Criteria:
• • Elderly aged 55 years or above
• • Both genders
• • Only right handed individuals
• • Elderly with a diagnosis of Minimal Cognitive Impairment and Mild AD according to National institute of Ageing -Alzheimer's Association (NIAAA) diagnostic Criteria and 0.5 for MCI and 1 according to CDR criteria.
• • Informed consent
• Exclusion Criteria:
• • Elderly with more advanced dementia (CDR \>1)
• • Patients on medications like antipsychotics, antidepressants and benzodiazepines (some of patients).
• • Patient with comorbid clinical conditions like hypothyroidism, hypercalcemia, vitamin B12 deficiency, niacin deficiency, neurosyphilis, normal pressure hydrocephalus or subdural haematoma.
• • Persons with other mental disorders like schizophrenia and related disorder, bipolar affective disorder, severe depression, obsessive compulsive disorder, substance dependence and mental retardation.
• • History of neurological illness like stroke, epilepsy, head injury with significant loss of consciousness or other chronic neurological/ neurodegenerative conditions.
• • Elderly Cognitively Healthy Comparison group (n=50)
• • Inclusion criteria
• • Elderly aged 55 years or above (age, gender and education matched with Dementia subjects)
• • Persons without MCI/AD (NIAAA Criteria)
• • Both genders, only right handed individuals.
• • Informed consent Exclusion criteria
• • Elderly with MCI or dementia (CDR ≥0.5)
• • Patients on medications like antipsychotics, antidepressants and benzodiazepines (some of patients).
• • Patient with comorbid clinical conditions like hypothyroidism, hypercalcemia, vitamin B12 deficiency, niacin deficiency, neurosyphilis, normal pressure hydrocephalus or subdural haematoma.
• • Persons with other mental disorders like schizophrenia and related disorder, bipolar affective disorder, severe depression, obsessive compulsive disorder, substance dependence and mental retardation.
• • History of neurological illness like stroke, epilepsy, head injury with significant loss of consciousness or other chronic neurological/ neurodegenerative conditions.