Genomic and Proteomic Analyses of Apoptosis Mechanisms in Diseased Peri-implant Tissue

Launched by SAKARYA UNIVERSITY · Mar 7, 2025

Keywords

ClinConnect Summary

The study received ethical approval from the Clinical Research Committee of Sakarya University Faculty of Medicine (Approval number: E-16214662-050.01.04-85,162-217) and was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. The study protocol was thoroughly explained to all participants, and written informed consent was obtained prior to their inclusion. Recruitment took place between March 2021 and June 2022, involving patients who attended the clinics of the Department of Periodontology, Sakarya University. These patients were either in the maint...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Partially or fully edentulous patients rehabilitated with single or multiple implant-supported prostheses
• • Dental implants with functional restorations in place for a minimum of one year, -at least one screw-type titanium implant (single or two-piece) diagnosed with peri-implant mucositis or peri-implantitis and requiring treatment (for diseased groups)
• • Non-smokers or former smokers (individuals who had quit smoking for at least five years prior to the study)
• Exclusion Criteria:
• • Systemic contraindications to dental or surgical treatments
• • Active periodontal disease
• • Pregnancy or lactation
• • Autoimmune or inflammatory diseases
• • Uncontrolled diabetes (HbA1c \> 7)
• • Ongoing corticosteroid therapy
• • Current smoking