Assessment of Methotreaxate-induced Liver Fibrosis by Transient Elastography and Serological Markers

Launched by ASSIUT UNIVERSITY · Mar 7, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how methotrexate, a common medication used to treat conditions like rheumatoid arthritis and psoriasis, can affect the liver over time. Researchers want to find out how often liver fibrosis, which is a thickening or scarring of the liver, happens in patients taking this medication. They will compare patients on methotrexate with those who have similar diseases but are not taking the medication. The study will also evaluate non-invasive tests, like the FibroScan, to see how well they can detect liver fibrosis compared to traditional methods like liver biopsies, which can be risky.

To participate in this trial, you need to be an adult over 18 years old who is currently taking methotrexate for certain rheumatological or dermatological diseases. However, if you have other liver diseases or specific heart or kidney issues, you won't be eligible. If you join the study, you can expect to go through tests that will help researchers understand how methotrexate affects the liver and find safer ways to monitor liver health without invasive procedures. This trial is important because it aims to improve the care and monitoring of patients on methotrexate, particularly in Egypt, where this topic has not been extensively studied.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (18 years and older) prescribed Methotrexate therapy for Rheumatological disease (such as Systemic Lupus Erythematosus , Rheumatoid arthritis and Ankylosing spondylitis)or Dermatological diseases (such as Psoriasis and Behcets disease).
• Exclusion Criteria:
• • Patients with metabolic associated fatty liver disease (MAFLD). Patients with chronic liver diseases (HBV, HCV, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, alcoholic liver disease).
• • History of chronic heart failure or renal failure.c.