Trophallergen Prick Tests : Influence of Food Sample Shelf Life on the Reproducibility of PT Results

Launched by CENTRE HOSPITALIER RÉGIONAL D'ORLÉANS · Mar 7, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how the shelf life of food samples affects the results of prick tests (PTs) used to diagnose food allergies. Prick tests are a common and safe way to check if someone is allergic to certain foods by introducing tiny amounts of the food into the skin. The goal of this study is to see if using fresh foods gives more reliable results compared to using stored foods that have been frozen or preserved for a while. This is important because many patients may not always have fresh food samples available during their allergy testing, and understanding the best practices for using stored foods could improve diagnosis and treatment.

To participate in this study, individuals must be 18 years or older and have a diagnosed food allergy that has caused serious allergic reactions (grade 2 or 3). Participants will undergo prick tests using both fresh and stored food samples to compare the results. It's worth noting that individuals with certain medical conditions or those recently hospitalized for severe allergies may not be eligible to join. This trial aims to improve allergy testing methods and ensure that patients receive the best possible care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged 18 and over.
• • 2. Having a diagnosis of food allergy(ies) due to one or more of the food allergen studied, previously made by an allergologist, of grade 2 to 3 according to the Ring and Messmer classification.
• • 3. Having given consent to participate in the study.
• • The diagnosis is made by the allergologist of the department due to the presence of a compatible clinical history implicating the tested allergen, the presence of evidence of sensitization to the allergen (positive prick-test and/or positive specific IgE assays), or even a positive oral allergen reintroduction test.
• Exclusion Criteria:
• • 1. Anaphylactic reaction dating less than 6 weeks
• • 2. Hospitalization for asthma in the past 3 months
• • 3. History of grade 4 anaphylactic reaction according to the Ring and Messmer classification.
• • 4. Systemic antihistamine treatment in the 7 days preceding the test
• • 5. Systemic beta-blocker treatment on the day of the test.
• • 6. Protected person (under guardianship or curatorship)
• • 7. Person under judicial supervision
• • 8. Persons deprived of liberty
• • 9. Person not affiliated with a social security insurance
• • 10. Pregnant or breastfeeding women