Albumin Infusion Targets on Mortality in Patients With Abdominal Sepsis

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · Mar 7, 2025

Keywords

ClinConnect Summary

Research Background Introduction to Sepsis and Abdominal Sepsis Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated immune response to infection. Abdominal sepsis, originating from intra-abdominal infections, is particularly challenging due to its high morbidity and mortality rates. The mortality rate for abdominal sepsis ranges from 7.6% to 36.0%, and it can reach up to 50% if it progresses to septic shock. The presence of hypoalbuminemia further complicates the clinical course and prognosis of sepsis patients.

Role of Albumin in Sepsis Albumin ...

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Eligibility criteria

• Inclusion Criteria:
• • Patients admitted to the Intensive Care Department of Southern Hospital of Southern Medical University from September 2017 to June 2022;
• • Age ≥ 18 years old;
• • Meeting the diagnostic criteria for abdominal infection;
• • Patients who meet the diagnostic criteria for sepsis/septic shock;
• • Complicated with hypoalbuminemia, i.e. plasma albumin\<30g/L after admission;
• • Human serum albumin injection was infused within 24 hours after check-in into the ICU.
• Exclusion Criteria:
• • Pregnant or lactating women
• • Patients who have not been able to obtain relevant diagnosis and treatment information after ICU check-in
• • Patients who repeatedly stay in the ICU
• • ICU hospitalization time is less than 24 hours
• • Pathological conditions that require albumin treatment in clinical practice (cirrhosis with ascites, post liver transplantation, intestinal malabsorption syndrome, nephrotic syndrome, burns);