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Search / Trial NCT06874725

Latent Tuberculosis in Type 2 Diabetes

Launched by TAICHUNG VETERANS GENERAL HOSPITAL · Mar 8, 2025

Trial Information

Current as of April 29, 2025

Active, not recruiting

Keywords

Latent Tuberculosis Infection Diabetes Observational Study

ClinConnect Summary

This clinical trial is studying how to prevent tuberculosis (TB) in people who have poorly controlled type 2 diabetes. Researchers are focusing on patients aged 45 and older who have high blood sugar levels (an HbA1c of 9% or more) and are screening them for latent tuberculosis infection (LTBI) using a test called QuantiFERON. If a patient tests positive for LTBI, they will receive treatment to help prevent active TB. This treatment can either be a daily pill called isoniazid taken for 9 months or a combination of isoniazid and another medication called rifapentine taken weekly for 3 months.

To join the trial, participants must be 45 years or older and have poorly controlled diabetes. However, individuals with active tuberculosis, those who are immunocompromised (meaning their immune system is weakened), or women who are currently pregnant cannot participate. Throughout the trial, doctors will monitor how well patients complete their treatment and check for signs of inflammation in their bodies. This trial is important as it aims to find effective ways to protect people with diabetes from developing active tuberculosis.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • aged ≥45 years
  • poorly controlled DM (pDM), defined as HbA1c ≥9% within the preceding year
  • Exclusion Criteria:
  • active TB
  • immunocompromise (use of immunosuppressors
  • current pregnancy

About Taichung Veterans General Hospital

Taichung Veterans General Hospital is a leading medical institution in Taiwan, renowned for its commitment to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, the hospital leverages its extensive expertise in various medical fields to facilitate the development of new therapies and improve patient outcomes. With a focus on patient-centered care and adherence to rigorous ethical standards, Taichung Veterans General Hospital plays a pivotal role in bridging the gap between research and clinical practice, fostering collaborations that contribute to the global medical community.

Locations

Taichung, , Taiwan

Patients applied

0 patients applied

Trial Officials

I-Te Lee

Principal Investigator

Taichung Veterans General Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported