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Search / Trial NCT06875492

Retrospective Cohort Study on the Impact of PDL Treatment History on the Efficacy of HMME-PDT in Treating PWS Children

Launched by SECOND AFFILIATED HOSPITAL OF XI'AN JIAOTONG UNIVERSITY · Mar 9, 2025

Trial Information

Current as of April 29, 2025

Completed

Keywords

Pulse Dye Laser Hemoporfin Pdt

ClinConnect Summary

Background Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) is considered a safe and effective treatment for port-wine stains (PWS). This study aims to investigate the influence of prior pulse dye laser (PDL) treatments history on the effectiveness of Hemoporfin-PDT in young children aged 1-3 years with PWS.

Methods Data was gathered for individuals with PWS aged 1-3 years who received two or more Hemoporfin-PDT treatments. The study population was stratified into two groups: Cohort 1 (No PDL) comprised patients without a history of PDL treatment, while Cohort 2 (Prior PDL) consis...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients clinically diagnosed with PWS (Port Wine Stain) who were between 1 and 3 years old at the time of their first HMME-PDT treatment.
  • Patients who, after evaluation by a clinician, are deemed eligible for HMME-PDT treatment and whose guardians have signed an informed consent form.
  • Patients who have undergone two or more HMME-PDT treatments.
  • ④ Patients with complete basic information and treatment-related information.
  • Exclusion Criteria:
  • Exclusion of patients with syndromes associated with PWS.
  • Exclusion of patients with a history of treatments for PWS other than PDL treatment.
  • Patients with other vascular malformations. ④ Exclusion of patients who have received any other PWS treatment within 2 months prior to HMME-PDT treatment.

About Second Affiliated Hospital Of Xi'an Jiaotong University

The Second Affiliated Hospital of Xi'an Jiaotong University is a leading medical institution in China, dedicated to advancing healthcare through innovative clinical research and patient care. Affiliated with one of the country's premier universities, the hospital combines clinical excellence with academic rigor, fostering a multidisciplinary approach to healthcare challenges. With a strong emphasis on patient-centered care, the hospital engages in a wide range of clinical trials aimed at improving treatment outcomes and enhancing medical knowledge. Its commitment to ethical standards and regulatory compliance ensures that all research initiatives prioritize patient safety and scientific integrity.

Locations

Xi'an, Shaanxi, China

Patients applied

0 patients applied

Trial Officials

Weihui Zeng

Study Chair

Second Affiliated Hospital of Xi'an Jiaotong University

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported