Long-term Longitudinal Imaging of Presynaptic Terminals in PD

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Mar 7, 2025

Keywords

ClinConnect Summary

This clinical trial is looking to understand how a specific protein, SV2A, changes in the brain as Parkinson's disease (PD) progresses. Researchers want to see if the loss of this protein moves from the lower parts of the brain to the outer parts over time, and whether this loss relates to changes in thinking and memory in people with PD. To do this, they will invite people who participated in a previous study about 7 years ago to join again, which will be about 10 years after they first noticed symptoms of PD.

Participants will include both individuals with Parkinson's disease and healthy volunteers. To be eligible, you must have taken part in the earlier study and not have any other major psychiatric or medical conditions. During the study, participants will undergo various tests, including brain scans and assessments of both movement and thinking skills. It's important to note that this study is not yet recruiting participants, but it aims to gather valuable information on how Parkinson’s affects brain health over time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participation in study S61477 (NCT04243304)
• Exclusion Criteria:
• • Neuropsychiatric diseases (unrelated to PD for PD patients)
• • Major internal medical diseases
• • History of alcohol or drug abuse
• • Relevant abnormalities on MR brain
• • Contraindications for MR
• • Pregnancy or breastfeeding
• • Previous participation in other research studies involving ionizing radiation with \> 1 mSv over past 12 months.