Long-term Longitudinal Imaging of Presynaptic Terminals in PD
Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Mar 7, 2025
Trial Information
Current as of April 26, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is looking to understand how a specific protein, SV2A, changes in the brain as Parkinson's disease (PD) progresses. Researchers want to see if the loss of this protein moves from the lower parts of the brain to the outer parts over time, and whether this loss relates to changes in thinking and memory in people with PD. To do this, they will invite people who participated in a previous study about 7 years ago to join again, which will be about 10 years after they first noticed symptoms of PD.
Participants will include both individuals with Parkinson's disease and healthy volunteers. To be eligible, you must have taken part in the earlier study and not have any other major psychiatric or medical conditions. During the study, participants will undergo various tests, including brain scans and assessments of both movement and thinking skills. It's important to note that this study is not yet recruiting participants, but it aims to gather valuable information on how Parkinson’s affects brain health over time.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Participation in study S61477 (NCT04243304)
- Exclusion Criteria:
- • Neuropsychiatric diseases (unrelated to PD for PD patients)
- • Major internal medical diseases
- • History of alcohol or drug abuse
- • Relevant abnormalities on MR brain
- • Contraindications for MR
- • Pregnancy or breastfeeding
- • Previous participation in other research studies involving ionizing radiation with \> 1 mSv over past 12 months.
About Universitaire Ziekenhuizen Ku Leuven
Universitaire Ziekenhuizen KU Leuven is a leading academic medical center in Belgium, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. Affiliated with KU Leuven, one of Europe’s premier universities, the institution integrates cutting-edge scientific inquiry with high-quality patient care. It plays a pivotal role in the development and implementation of clinical trials, fostering collaboration between researchers, healthcare professionals, and industry partners to translate scientific discoveries into effective treatments. The hospital's multidisciplinary approach ensures comprehensive patient safety and ethical standards, positioning it as a trusted sponsor in the realm of clinical research.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Leuven, , Belgium
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported