Sarcopenic Obesity: Estimation of Prevalence and Identification of Clinical and Biological Determinants in a Cohort of Adult Obese Patients and Longitudinal Follow-up

Launched by UNIVERSITY HOSPITAL, CLERMONT-FERRAND · Mar 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a condition called sarcopenic obesity (SO), which occurs when a person has both excess body fat and a loss of muscle mass. The research aims to find out how common sarcopenic obesity is among adults aged 18 to 70 who are considered obese, which means they have a body mass index (BMI) over 30. The goal is to identify the factors that contribute to muscle loss in people with obesity, especially since this condition is often overlooked in younger adults compared to older individuals.

To participate in this study, you need to be between 18 and 70 years old, be a man or woman, and have a BMI over 30. You also need to be receiving nutritional care to help manage your health. Unfortunately, individuals with certain severe health issues, such as cancer or serious muscle diseases, cannot take part in the trial. If you join, you can expect to be followed over a period of 5 to 10 years to see how your body composition and muscle function change. Additionally, there will be a shorter follow-up for those who have had weight loss surgery to understand how quick weight loss affects muscle health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: 18-70
• • Sex: men and women
• • Clinical nutrition patient receiving a metabolic assessment to optimise clinical and paraclinical management
• • Patient meeting obesity criteria defined by BMI \> 30 kg/m².
• • Patient of legal age who has given free, informed and signed consent
• • Patient covered by social security
• Non-inclusion criteria :
• • Patients with cancer or severe chronic disease (renal failure, respiratory failure, liver failure)
• • Patients with neuromuscular disease
• • Patient with total walking disability
• • Patients who are minors
• • Patient refusing to take part in the study
• • Pregnant or breast-feeding women
• • Under guardianship, curatorship, deprived of liberty or under court protection
• • Patient who has taken part in the OBESAR study