Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids

Launched by UNIVERSITY OF NEBRASKA · Mar 14, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at the effects of butyric acid, a substance that may help improve gut health, in young children who have congenital heart disease (CHD) and will be undergoing heart surgery. Researchers want to see if giving butyric acid before surgery is safe and if it can help reduce inflammation and improve gut function in these children. The trial will include infants and children aged 1 month to 3 years who will have surgery that requires a special machine called a cardiopulmonary bypass, which helps the heart and lungs work while the surgery is happening.

To participate, children must be scheduled for cardiac surgery and not have had antibiotics, surgery, or chemotherapy in the eight weeks before the study. They also should not be receiving certain types of feeding or have specific digestive system issues. During the trial, participants will receive butyric acid and be monitored for any side effects, as well as changes in their gut health. This study is important because it could provide new insights into how to support the health of young children with CHD during their recovery from surgery. The trial is not yet recruiting participants, but it aims to help improve care for these patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Infants and Children undergoing cardiac surgery with cardiopulmonary bypass
• Exclusion Criteria:
• • Antibiotics, surgery, or chemotherapy within the past 8 weeks
• • Continuous enteral feeds before surgery
• • GI pathology or intestinal surgery (excluding G-tube)
• • Liver disease with elevated transaminitis or dialysis-dependent renal disease