Clinical Relevance of Pathologic Regression IN Lymph Node for Locally Advanced Rectal Cancer
Launched by YANHONG DENG · Mar 12, 2025
Trial Information
Current as of May 09, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
This large-scale, multi-center cohort study investigates the clinical significance of Pathologic Regression in lymph nodes (LNs) of patients with Locally Advanced Rectal Cancer (LARC) following Neoadjuvant Chemoradiotherapy (NCRT). Additionally, it compares the efficacy of diverse NCRT regimens in achieving pathologic regression and improving survival outcomes.
Study Design Type: Retrospective and prospective observational cohort study. Setting: Multi-center collaboration across 14 academic and community hospitals. Timeframe: Data from patients treated between 2014 and 2025 will be analyze...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • - Adults (≥18 years) diagnosed with locally advanced rectal adenocarcinoma (clinical stage II-III).
- • Completion of NCRT followed by curative-intent surgery. Availability of pre- and post-treatment histopathologic data, including standardized regression grading and digitized whole-slide images (WSIs).
- Exclusion Criteria:
- • - distant Metastatic disease at diagnosis. Incomplete clinical or pathologic records.
About Yanhong Deng
Yanhong Deng is a dedicated clinical trial sponsor committed to advancing medical research and innovation through rigorous scientific evaluation. With a focus on improving patient outcomes, Yanhong Deng collaborates with leading healthcare professionals and institutions to design and implement clinical trials that adhere to the highest ethical and regulatory standards. The organization emphasizes transparency, safety, and efficacy in its research initiatives, striving to contribute valuable insights to the medical community and enhance therapeutic options for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported