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Search / Trial NCT06883084

Clinical Relevance of Pathologic Regression IN Lymph Node for Locally Advanced Rectal Cancer

Launched by YANHONG DENG · Mar 12, 2025

Trial Information

Current as of April 22, 2025

Enrolling by invitation

Keywords

ClinConnect Summary

This large-scale, multi-center cohort study investigates the clinical significance of Pathologic Regression in lymph nodes (LNs) of patients with Locally Advanced Rectal Cancer (LARC) following Neoadjuvant Chemoradiotherapy (NCRT). Additionally, it compares the efficacy of diverse NCRT regimens in achieving pathologic regression and improving survival outcomes.

Study Design Type: Retrospective and prospective observational cohort study. Setting: Multi-center collaboration across 14 academic and community hospitals. Timeframe: Data from patients treated between 2014 and 2025 will be analyze...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • - Adults (≥18 years) diagnosed with locally advanced rectal adenocarcinoma (clinical stage II-III).
  • Completion of NCRT followed by curative-intent surgery. Availability of pre- and post-treatment histopathologic data, including standardized regression grading and digitized whole-slide images (WSIs).
  • Exclusion Criteria:
  • - distant Metastatic disease at diagnosis. Incomplete clinical or pathologic records.

About Yanhong Deng

Yanhong Deng is a dedicated clinical trial sponsor committed to advancing medical research and innovation through rigorous scientific evaluation. With a focus on improving patient outcomes, Yanhong Deng collaborates with leading healthcare professionals and institutions to design and implement clinical trials that adhere to the highest ethical and regulatory standards. The organization emphasizes transparency, safety, and efficacy in its research initiatives, striving to contribute valuable insights to the medical community and enhance therapeutic options for patients worldwide.

Locations

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported