Clinical Relevance of Pathologic Regression IN Lymph Node for Locally Advanced Rectal Cancer

Launched by YANHONG DENG · Mar 12, 2025

Keywords

ClinConnect Summary

This large-scale, multi-center cohort study investigates the clinical significance of Pathologic Regression in lymph nodes (LNs) of patients with Locally Advanced Rectal Cancer (LARC) following Neoadjuvant Chemoradiotherapy (NCRT). Additionally, it compares the efficacy of diverse NCRT regimens in achieving pathologic regression and improving survival outcomes.

Study Design Type: Retrospective and prospective observational cohort study. Setting: Multi-center collaboration across 14 academic and community hospitals. Timeframe: Data from patients treated between 2014 and 2025 will be analyze...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Adults (≥18 years) diagnosed with locally advanced rectal adenocarcinoma (clinical stage II-III).
• • Completion of NCRT followed by curative-intent surgery. Availability of pre- and post-treatment histopathologic data, including standardized regression grading and digitized whole-slide images (WSIs).
• Exclusion Criteria:
• • - distant Metastatic disease at diagnosis. Incomplete clinical or pathologic records.