Effect of Mannitol on Propofol Level

Launched by CUKUROVA UNIVERSITY · Mar 18, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a substance called mannitol affects the levels of a medication called propofol during surgery. Mannitol is sometimes used to help reduce swelling in the brain, and it will be given to one group of patients who are having surgery for brain tumors. A second group of patients will have a different type of surgery, for pituitary tumors, but they will not receive mannitol. Researchers will compare the propofol levels in both groups to see if mannitol makes a difference.

To join this trial, patients need to be between 18 and 75 years old and classified as ASA II, which means they have mild to moderate health issues. They should be scheduled for either supratentorial tumor surgery (for brain tumors) or pituitary surgery. Participants can expect to have blood and urine samples taken during their surgery to measure the propofol levels. This study is not yet recruiting, so it’s still in the planning stages.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • American Society of Anesthesiologist (ASA) II participants
• • supratentorial tumor surgery
• • eligible for mannitol use
• • eligible for Total intravenous anesthesia (TIVA)
• Exclusion Criteria:
• • American Society of Anesthesiologist (ASA) III and upper
• • Chronic kidney failure
• • sepsis
• • multiorgan failure