Effect of Mannitol on Propofol Level

Launched by CUKUROVA UNIVERSITY · Mar 18, 2025

Keywords

ClinConnect Summary

The participants will divide into the two groups. Group 1 will include 20 patients aged 18 years and over, American Society of Anesthesiologist (ASA) II-III class, who will undergo supratentorial tumor surgery, (Mannitol group) and Group 2 will include 20 patients who will undergo pituitary surgery without mannitol (Control Group). Total intravenous anesthesia (TIVA) will be adjusted to propofol 4 µg/dl and remifentanil 2-4 µg/dl with target-controlled infusion pumps. In the mannitol group, 2.5 ml/kg (0.5 g/kg) will be given to all patients 15 minutes after induction and the mannitol infusi...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • American Society of Anesthesiologist (ASA) II participants
• • supratentorial tumor surgery
• • eligible for mannitol use
• • eligible for Total intravenous anesthesia (TIVA)
• Exclusion Criteria:
• • American Society of Anesthesiologist (ASA) III and upper
• • Chronic kidney failure
• • sepsis
• • multiorgan failure