Mpox Comprehensive Assessment for Responsive Immunisation in Emergency Outbreaks
Launched by UNIVERSITY OF BIRMINGHAM · Mar 19, 2025
Trial Information
Current as of April 26, 2025
Recruiting
Keywords
ClinConnect Summary
The Mpox Comprehensive Assessment for Responsive Immunisation in Emergency Outbreaks study is looking to understand more about mpox, a viral infection, by gathering health information and biological samples from different groups of people. The goal is to develop better tests and vaccines to help manage mpox outbreaks in the future. Researchers are currently recruiting participants of all genders aged between 5 and 80 who are healthy and willing to take part in the study. There are three groups: one group includes people who may have been exposed to mpox, another includes those who have had mpox or have been vaccinated against it, and the third group consists of people with no symptoms or known exposure to the virus.
If you participate, you can expect to provide some health information and biological samples, like blood, that will help researchers learn more about the immune response to mpox. It's important to know that there are certain criteria that can exclude you from joining, such as having a known immune disorder, being pregnant, or having recent symptoms of mpox. This study aims to enhance our understanding of mpox so that better prevention and treatment options can be developed for everyone.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Healthy males and females aged between ages 5-80 years, who are able and willing to provide informed consent and will comply with the study requirements.
- • Group 1 (suspected exposure cohort) only
- • Live within or adjacent to an epidemiologically identified region of Mpox transmission
- • Close contacts of those with microbiologically confirmed Mpox
- • Group 2 (post-exposure/vaccinated cohort) only
- • Previous clinically or microbiologically confirmed Mpox or confirmed previous vaccination with a smallpox/MVA vaccine
- • Fully recovered from Mpox infection
- * Group 3 (control cohort) only:
- • Asymptomatic with no known exposure to Mpox
- Exclusion Criteria:
- • Unwilling or unable to provide informed consent to take part
- • Unwilling or unable to comply with study procedures
- • History of any suspected or confirmed disorder of the immune system that, in the opinion of the investigators, might impair the results of the study
- • Have a bleeding disorder deemed significant by a member of the study team
- • Pregnant or breast-feeding females
- • Group 1 (suspected exposure cohort) only
- • Known history of Mpox infection
- • Current symptoms consistent with Mpox
- • Known exposure to Mpox in the last month
- • Group 2 (post-exposure/vaccinated cohort) only
- • Participants with any ongoing symptoms of Mpox, indicating incomplete recovery.
- • Group 3 (control cohort only)
- • Symptoms of Mpox
- • Known exposure to Mpox in the last month
About University Of Birmingham
The University of Birmingham is a leading research institution in the UK, renowned for its commitment to advancing medical science and improving health outcomes through innovative clinical research. With a strong emphasis on collaboration, the university engages in multidisciplinary studies that leverage cutting-edge technology and expertise across various fields. Its dedicated clinical trial infrastructure supports rigorous investigation and the ethical conduct of research, ensuring that findings contribute meaningfully to the scientific community and public health. Through its initiatives, the University of Birmingham aims to translate research discoveries into tangible benefits for patients and healthcare systems alike.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Kigali, , Rwanda
Patients applied
Trial Officials
Christopher Green
Principal Investigator
University of Birmingham
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported