Effect of Dialysate Cooling Versus Sodium Profiling in Management of Intradialytic Hypotension Among Chronic Hemodialysis Patients

Launched by ASSIUT UNIVERSITY · Mar 17, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring two different methods to help manage a common problem faced by patients undergoing dialysis called intradialytic hypotension (IDH), which is when blood pressure drops during the treatment. The trial will compare the effects of cooling the dialysis fluid to a lower temperature against a traditional method called sodium profiling. The goal is to see which method is more effective in reducing episodes of low blood pressure during dialysis, improving overall well-being after treatment, and helping patients achieve their ideal weight post-dialysis.

To participate in the trial, you need to be between the ages of 18 and 70, have been on hemodialysis for at least six months, and have experienced episodes of low blood pressure during treatment. People with severe anemia, those on certain medications for blood pressure, or those who do not comply with treatment may not be eligible. If you join the study, you can expect to undergo dialysis with either the cooled fluid or the standard method, and your health will be monitored throughout the process. This trial is important because it aims to find a simple way to improve the safety and comfort of dialysis for many patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Patients age 18-70 years old.
• • Maintained on HD for not less than 6 months
• • Documented episodes of IDH
• Exclusion Criteria:
• • • Severly anemic patients (Hb\<7 g/dl)
• • Patients taking more than 3 antihypertensive (on days other than dialysis day).
• • Patients with documented IHD.
• • Patients on midodraine therapy prior dialysis session.
• • patient refusal, incompliance or ineffective dialysis.