Single-Dose Hybrid Hyaluronic Acid and Sodium Chondroitin with Rehabilitation for Sports Adults with Knee Osteoarthritis

Launched by UNIVERSITY OF PALERMO · Mar 16, 2025

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Eligibility criteria

• Inclusion Criteria:
• • Adults aged between 18 and 50 years.
• • Radiologically confirmed diagnosis of knee osteoarthritis (Kellgren-Lawrence grade ≤3), present for at least 6 months.
• • Persistent moderate to severe pain due to osteoarthritis, interfering with physical performance.
• • Documented reduction in sports performance (use appropriate scales or tests to validate this).
• • Lack of response to pharmacological or other conservative treatments.
• • Willingness to provide written informed consent for participation.
• Exclusion Criteria:
• • Coexisting rheumatic diseases.
• • History of intra-articular viscosupplementation in the target knee within the previous 6 months.
• • Presence of significant venous or lymphatic stasis.
• • Body Mass Index (BMI) ≥ 30 kg/m².
• • Use of systemic or intra-articular corticosteroids in the target knee within the last 3 months.
• • Chronic use of topical/systemic analgesics, NSAIDs, or narcotics.
• • History of alcohol or drug abuse.
• • Allergy or hypersensitivity to hyaluronic acid or any of its components.
• • Pregnant or breastfeeding women, or those not using adequate contraception.