Impact of Home-Based Aerobic and Resistance Training in Chronic Liver Disease: a Randomized Control Trial

Launched by HACETTEPE UNIVERSITY · Mar 18, 2025

Keywords

ClinConnect Summary

This randomized controlled trial was designed to evaluate the effects of an 8-week home-based exercise program on physical and health-related outcomes in patients with Chronic Liver Disease (CLD). The study included three groups: Aerobic Exercise (AE), Aerobic and Resistance Exercise (ARE), and a control group. Below are the details of the interventions and measurement techniques utilized in the study.

Study Groups and Interventions

1. Aerobic Exercise (AE) Group:

Exercise Protocol: Participants engaged in moderate-intensity walking exercises three non-consecutive days per week. The i...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Being followed up for chronic liver disease or listed on the liver transplant waiting list at the Hacettepe University Department of Internal Medicine, Division of Gastroenterology.
• • Owning and being able to use a smartphone.
• • Aged between 18 and 70 years.
• • Receiving primary prophylactic treatment for gastroesophageal varices.
• • Willingness to participate in the study.
• Exclusion Criteria:
• • Inability to own or use a smartphone.
• • Participation in an exercise training program within the last year.
• • Previous liver transplantation.
• • High-risk varices without beta-blocker treatment.
• • Presence of persistent hepatic encephalopathy.
• • Hepatic hydrothorax.
• • Pulmonary vascular complications of portal hypertension.
• • Chronic renal failure requiring dialysis.
• • Hemoglobin level below 10 g/dL.
• • Creatinine level above 2 mg/dL.
• • Human Immunodeficiency Virus (HIV) infection.
• • Presence of hepatocellular carcinoma (HCC).
• • Recent acute myocardial infarction.
• • Uncontrolled arrhythmias causing symptomatic hemodynamic instability.
• • Contraindications to maximal exercise testing.
• • Physical or orthopedic conditions preventing home-based exercise training.
• • Lack of willingness to participate in the study.