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Search / Trial NCT06892366

Impact of Home-Based Aerobic and Resistance Training in Chronic Liver Disease: a Randomized Control Trial

Launched by HACETTEPE UNIVERSITY · Mar 18, 2025

Trial Information

Current as of April 29, 2025

Completed

Keywords

End Stage Liver Disease Exercise Sarcopenia

ClinConnect Summary

This randomized controlled trial was designed to evaluate the effects of an 8-week home-based exercise program on physical and health-related outcomes in patients with Chronic Liver Disease (CLD). The study included three groups: Aerobic Exercise (AE), Aerobic and Resistance Exercise (ARE), and a control group. Below are the details of the interventions and measurement techniques utilized in the study.

Study Groups and Interventions

1. Aerobic Exercise (AE) Group:

Exercise Protocol: Participants engaged in moderate-intensity walking exercises three non-consecutive days per week. The i...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Being followed up for chronic liver disease or listed on the liver transplant waiting list at the Hacettepe University Department of Internal Medicine, Division of Gastroenterology.
  • Owning and being able to use a smartphone.
  • Aged between 18 and 70 years.
  • Receiving primary prophylactic treatment for gastroesophageal varices.
  • Willingness to participate in the study.
  • Exclusion Criteria:
  • Inability to own or use a smartphone.
  • Participation in an exercise training program within the last year.
  • Previous liver transplantation.
  • High-risk varices without beta-blocker treatment.
  • Presence of persistent hepatic encephalopathy.
  • Hepatic hydrothorax.
  • Pulmonary vascular complications of portal hypertension.
  • Chronic renal failure requiring dialysis.
  • Hemoglobin level below 10 g/dL.
  • Creatinine level above 2 mg/dL.
  • Human Immunodeficiency Virus (HIV) infection.
  • Presence of hepatocellular carcinoma (HCC).
  • Recent acute myocardial infarction.
  • Uncontrolled arrhythmias causing symptomatic hemodynamic instability.
  • Contraindications to maximal exercise testing.
  • Physical or orthopedic conditions preventing home-based exercise training.
  • Lack of willingness to participate in the study.

About Hacettepe University

Hacettepe University is a leading research institution in Turkey, renowned for its commitment to advancing medical science and healthcare through innovative clinical research. With a strong emphasis on interdisciplinary collaboration, the university supports a wide range of clinical trials aimed at improving patient outcomes and developing new therapeutic approaches. Hacettepe University is dedicated to maintaining the highest ethical standards and regulatory compliance in its research endeavors, fostering an environment that promotes scientific excellence and contributes to the global body of medical knowledge.

Locations

Ankara, Altındağ, Turkey

Patients applied

0 patients applied

Trial Officials

Naciye Vardar Yağlı, Prof

Study Director

Hacettepe University Faculty of Physical Therapy and Rehabilitation

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported