Phase-Aligned Atrial Fibrillation Mapping

Launched by THE CLEVELAND CLINIC · Mar 19, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring a new method for treating atrial fibrillation (AF), a type of irregular heartbeat that can lead to serious health issues. The researchers want to improve how doctors find the precise areas in the heart that need to be treated by using a technique that analyzes electrical signals inside the heart. By creating a detailed electric map, they hope to increase the chances of successfully curing patients with AF. The study will look at data from patients who have undergone a specific procedure called pulmonary vein isolation (PVI) to see how well this new mapping technique works compared to traditional methods.

To be eligible for this study, participants need to have experienced persistent atrial fibrillation, meaning their AF lasted longer than seven days, and must have had their first ablation procedure to treat it. They also need to have good quality data on their heart's activity after the procedure to help determine if their AF came back within a year. If you or a loved one fits these criteria and has undergone this treatment, your participation could help shape future technologies for better AF care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Records of patients with persistent AF who underwent pulmonary vein isolation (PVI) with any additional AF ablation strategy with available stored digital AF mapping data. Persistent AF is defined as AF lasting more than 7 days.
• • 2. One/First AF ablation procedure (no prior atrial ablation procedures)
• • 3. Documented complete pulmonary vein isolation at the end of the ablation
• • 4. Available uniform, high-quality (as described below) clinical data required to detect AF recurrence during ≥ 1 year after ablation, and/or ECG monitoring (implantable loop recording or repeated long-term ECG monitoring via ECG patch or similar)
• Exclusion Criteria:
• • 1. Familial AF, AF as a syndrome in rare diseases (cardiomyopathies / WPW/ channelopathies).
• • 2. Missing data of exposure (AF ablation map), outcome (definition of cases and controls), or covariates