Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.

Launched by NORTHWESTERN UNIVERSITY · Mar 19, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how certain factors can help predict whether patients with chronic rhinosinusitis with nasal polyps (CRSwNP) will regain their sense of smell after being treated with a medication called dupilumab. The researchers want to find out if the blockage in a specific area of the nose, known as the olfactory cleft, and certain signals measured during breathing can indicate if a person will be able to smell again.

To participate in the study, candidates should be between the ages of 18 and 75, have a well-documented history of CRSwNP, and report experiencing a significant loss of smell for at least three months. Participants will have their olfactory cleft examined and monitored for six months while receiving treatment with dupilumab. This study is not yet recruiting, but if you're eligible, it could provide valuable insights into how this treatment affects the sense of smell.

Gender

ALL

Eligibility criteria

• • Well documented history of CRSwNP
• • BSIT age/sex classified as "abnormal" score
• • Self-reported stable olfactory deficit of moderate to severe quality \> 3 months
• • Prior endoscopic sinus surgery \>3 months, \<10 years prior