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Search / Trial NCT06892704

Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.

Launched by NORTHWESTERN UNIVERSITY · Mar 19, 2025

Trial Information

Current as of April 29, 2025

Not yet recruiting

Keywords

Dupilumab Chronic Rhinosinusitis With Nasal Polyps Smell Loss Electrophysiology

ClinConnect Summary

This clinical trial is looking at how certain factors can help predict whether patients with chronic rhinosinusitis with nasal polyps (CRSwNP) will regain their sense of smell after being treated with a medication called dupilumab. The researchers want to find out if the blockage in a specific area of the nose, known as the olfactory cleft, and certain signals measured during breathing can indicate if a person will be able to smell again.

To participate in the study, candidates should be between the ages of 18 and 75, have a well-documented history of CRSwNP, and report experiencing a significant loss of smell for at least three months. Participants will have their olfactory cleft examined and monitored for six months while receiving treatment with dupilumab. This study is not yet recruiting, but if you're eligible, it could provide valuable insights into how this treatment affects the sense of smell.

Gender

ALL

Eligibility criteria

  • Well documented history of CRSwNP
  • BSIT age/sex classified as "abnormal" score
  • Self-reported stable olfactory deficit of moderate to severe quality \> 3 months
  • Prior endoscopic sinus surgery \>3 months, \<10 years prior

About Northwestern University

Northwestern University is a prestigious academic institution renowned for its commitment to advancing medical research and improving patient care through innovative clinical trials. With a robust infrastructure that supports interdisciplinary collaboration, Northwestern leverages its expertise in various fields, including medicine, engineering, and social sciences, to drive groundbreaking studies. The university is dedicated to adhering to the highest ethical standards and regulatory compliance, ensuring that all clinical trials are conducted with the utmost integrity and focus on participant safety. Through its Clinical Trials Office, Northwestern aims to translate scientific discoveries into effective therapies, ultimately enhancing health outcomes and contributing to the broader medical community.

Locations

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported