Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy

Launched by HOSPITAL FOR SPECIAL SURGERY, NEW YORK · Mar 18, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether using bone marrow aspirate (BMA) injections during knee surgery can help patients feel better and recover faster. The study will enroll 50 people who need knee surgery for issues like meniscus injuries or cartilage damage. Participants will be divided into two groups: one group will receive the standard surgery along with a BMA injection taken from their hip, while the other group will receive the same surgery but with a saline (salt water) injection instead. Over the course of a year, patients will answer questions about their pain and how well they can move their knee at various times, helping the researchers see if the BMA makes a difference.

To be eligible for this trial, participants should be between 18 and 55 years old and need knee surgery for a meniscus injury or a specific type of cartilage damage. They should not have severe arthritis or have had any recent knee surgeries. Participants can expect to be monitored for 12 months and will help researchers learn more about the effectiveness of using bone marrow injections in knee surgeries. This study is not yet recruiting, so there's time to learn more before deciding to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Require a primary knee arthroscopy for a meniscal injury or focal chondral defect (knee debridement or meniscectomy)
• • 2. Have Kellgren-Lawrence grade 0 arthritis
• • 3. Have Outerbridge cartilage grade 2 or lower
• • 4. Ages 18-55
• Exclusion Criteria:
• • 1. Have previously undergone ipsilateral knee surgery
• • 2. Have Kellegren-Lawrence grade 3 or greater
• • 3. Have received other OrthoBiologics within 6 mo of surgery
• • 4. Have ligament deficiencies
• • 5. Need meniscal repair
• • 6. Need a concomitant osteotomy or other realignment surgery
• • 7. Have used DMARDs within the last three months
• • 8. Have a hx of anemia, bleeding disorders, or inflammatory joint disease (rheumatoid arthritis, infectious arthritis, hemophilic arthropathy, Charcot's knee)
• • 9. Have a hx of metabolic bone disease (osteoporosis, osteomalacia, rickets, osteitis fibrosa cystica, Paget's disease of bone)
• • 10. Have had a prior steroid injection
• • 11. Patients who are currently pregnant