Intrathecal Cytarabine, Methotrexate, and Hydrocortisone for the Prevention of High-Grade Chimeric Antigen Receptor T-Cell-Associated Neurotoxicity Syndrome

Launched by OHSU KNIGHT CANCER INSTITUTE · Mar 19, 2025

Keywords

ClinConnect Summary

PRIMARY OBJECTIVE:

I. To evaluate the efficacy of IT chemotherapy in the prevention of high grade ICANS.

SECONDARY OBJECTIVES:

I. To evaluate the efficacy of IT chemotherapy in the prevention of any grade ICANS.

II. To evaluate safety of IT chemotherapy. III. To evaluate the effect of IT chemotherapy on corticosteroid use. IV. To evaluate the effect of IT chemotherapy on anakinra use.

EXPLORATORY OBJECTIVES:

I. To evaluate the effect of IT chemotherapy on time to ICANS onset. II. To evaluate the effect of IT chemotherapy on duration of ICANS. III. To evaluate the burden of treatment m...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Written informed consent. Participant or legally authorized representative (LAR) must provide written informed consent prior to any study-specific procedures or interventions
• • Age ≥ 18 years. All genders, races, and ethnic groups will be included
• • Must be receiving SOC Yescarta® or Tecartus® in the inpatient setting
• • Agree to adhere to institutional guidelines for contraception during the first 30 days post CAR-T
• • Rationale for eligibility criteria based on contraception and pregnancy (both participants and partners of a sperm-producing participant): It shall be known to all participants that the effects of CAR-T or IT chemotherapy on the developing human fetus are unknown. For this reason, persons of reproductive potential must agree to use adequate contraception. Should a participant or participant's sexual partner become pregnant or suspect a pregnancy while participating in this study, the individual should inform their treating physician immediately
• • Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
• • Platelet count \> 50,000/mm\^3 (μL)
• • Adequate coagulation tests including international normalized ratio (INR) \< 1.6 and fibrinogen \> 100
• Exclusion Criteria:
• • Active/concurrent diagnosis of any central nervous system (CNS) hematologic malignancy
• • History or presence of CNS disorder such as seizure disorder, cerebrovascular ischemia/hemorrhage, dementia, cerebellar disease, or any autoimmune disease with CNS involvement
• • Known history of hypersensitivity to IT chemotherapy
• * Subject has a contraindication to LP including:
• • Presence of a posterior fossa mass
• • Skin infection near puncture site
• • Uncorrected bleeding diathesis
• • Suspicion of increased intracranial pressure
• • Acute spinal cord trauma
• • Subject is receiving an antiplatelet and/or anticoagulant that cannot be held prior to LP according to best available evidence
• • Known bleeding disorders
• • Any other significant medical illness, abnormality, or condition that would, in the Investigator's judgement, make the participant inappropriate for study participation or would put the participant at risk

Trial Officials