An Observational Study for Gastric Cancer in Asymptomatic Carriers of High Risk Helicobacter Pylori

Launched by FUDAN UNIVERSITY · Mar 20, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the link between a specific type of bacteria called Helicobacter pylori (Hp) and the development of stomach cancer in people who do not have symptoms but carry a high-risk version of this bacteria. The researchers want to observe how often stomach cancer occurs and how any early signs of cancer progress in individuals with different types of Hp. The study aims to gather information from participants over time to better understand these risks.

To be eligible for this study, participants need to be at least 18 years old and must not have a history of stomach cancer. They should also be healthy enough to undergo testing, including breath tests or stomach biopsies, to check for Hp. Participants will not have any serious stomach problems or immediate medical needs. If someone joins the study, they can expect to have regular check-ups and tests to monitor their health. It's important to note that the study is not currently recruiting participants, so interested individuals will need to wait until it begins.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years old, gender is not limited;
• • 2. No previous history of gastric cancer (no radical surgery or radiotherapy treatment for gastric cancer);
• • 3. Able and willing to provide informed consent and willing to accept baseline and follow-up examinations;
• • 4. Able to cooperate in completing HP testing (breath test, gastroscopic biopsy or other standard testing methods) and HP SNP typing by stool testing;
• • 5. No obvious gastric symptoms at the time of initial screening, no progressive gastric cancer or serious gastric diseases (e.g., perforated acute ulcers, upper gastrointestinal hemorrhage, etc.) detected, and no need for urgent surgery (not planned within 3 months) or other therapeutic interventions for the time being.
• Exclusion Criteria:
• • 1. Diagnosed gastric cancer or other malignant tumors of the digestive tract;
• • 2. Comorbid serious underlying diseases (e.g., severe cardiopulmonary insufficiency, liver and renal failure, etc.) that are expected to have a short survival time or are not suitable for long-term follow-up;
• • 3. Inability to complete or refusal to undergo HP testing, SNP gene testing or follow-up;
• • 4. Presence of severe mental illness or incapacity for civil behavior that prevents completion of the study;
• • 5. Pregnant or breastfeeding women who are temporarily excluded;
• • 6. Other conditions that the investigator considers unsuitable for participation in this study.