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Search / Trial NCT06896578

Latitude - Lateral Lymph Node Attitude Study

Launched by SAHLGRENSKA UNIVERSITY HOSPITAL · Mar 19, 2025

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Trial Information

Current as of April 22, 2025

Not yet recruiting

Keywords

Lateral Lymph Nodes Quality Of Life Local Recurrence Thrombosis Lymph Oedema Lateral Lymph Node Dissection

ClinConnect Summary

Patients with advanced rectal cancer will receive standard care, if lateral lymph nodes exist after neoadjuvant treatment they will be operated accordingly. The focus will be to compare two groups (with and without lateral lymph node clearance) regarding function, QoL and oncologic outcome.

We will also aim to identify features on MRI to improve diagnostic ability.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • 18 years or older
  • • written informed consent
  • • adenocarcinoma verified tumour below ≤ 8 cm from anal verge measured by rectoscopy and/or MRI
  • • clinical tumor (cT) stage cT3, cT4a or cT4b on MRI or
  • • adenocarcinoma verified tumour at any height ≤ 15 cm from anal verge measured by rectoscopy and/or MRI regardless of T/N stage with visible lateral lymph node (according to definition 2.4.2) on pre-therapeutic MRI or PET-CT
  • Exclusion Criteria:
  • • Not biopsy confirmed rectal cancer (adenocarcinoma)
  • • Recurrent rectal cancer
  • • Age below 18
  • • Participation in other trials in conflict with the protocol and end-points of the Latitude study
  • • No informed consent

Trial Officials

Eva Angenete, MD PhD

Principal Investigator

Sahlgrenska Universitetssjukhuset

About Sahlgrenska University Hospital

Sahlgrenska University Hospital, a leading healthcare institution in Sweden, is at the forefront of clinical research and innovation. Affiliated with the University of Gothenburg, the hospital integrates advanced medical care with cutting-edge research, facilitating a collaborative environment for scientific exploration and clinical trials. With a commitment to improving patient outcomes, Sahlgrenska University Hospital focuses on a wide range of therapeutic areas, leveraging its multidisciplinary expertise to advance healthcare solutions. The institution is dedicated to fostering ethical research practices and ensuring the highest standards of patient safety and care in all clinical trials.

Locations

Gothenburg, , Sweden

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported