Disease Burden Transition of Mucormycosis in Hematologic Malignancies Population Across Covid 19 Era: a Single-center Comparative Analysis From China

Launched by INSTITUTE OF HEMATOLOGY & BLOOD DISEASES HOSPITAL, CHINA · Mar 26, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a serious fungal infection called mucormycosis, which can affect patients with blood cancers (hematologic malignancies) who have received a specific type of treatment known as hematopoietic stem cell transplantation. The researchers aim to understand how the incidence, diagnosis, and treatment of mucormycosis have changed during the COVID-19 pandemic. They will look at factors like the signs and symptoms of the infection, how patients were diagnosed and treated, and the overall impact on healthcare costs. This information will help improve care for future patients undergoing stem cell transplants who may develop mucormycosis.

To be eligible for this study, participants must be at least 18 years old and have received a stem cell transplant at the study center between January 2015 and December 2023. They must also have a confirmed diagnosis of mucormycosis. Participation involves reviewing medical records, so patients or their authorized representatives will need to agree to take part and provide consent. It's important to note that patients with other types of fungal infections will not be included in this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with hematologic diseases who undergoes hematopoietic stem cell transplantation in the center from January 2015 to December 2023.
• • 2. Age≥18 years old.
• • 3. Patients who were diagnosed with mucormycosis(proven or probable) in accordance with the 2008 EORTC/MSG criteria and Revised EORTC/MSGERC 2020 Criteria.\[8\]\[9\].
• • 4. The patients themselves or their authorized clients agree to participate in the clinical study and sign the informed consent.
• Exclusion Criteria:
• • 1. Patients with fungal infections other than mucormycosis were excluded.