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Search / Trial NCT06901206

Neonatologist-Performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy

Launched by ROYAL HOSPITAL FOR WOMEN · Mar 23, 2025

Trial Information

Current as of April 22, 2025

Not yet recruiting

Keywords

Nplus Neonatologist Performed Lung Ultrasound Lung Ultrasound Score Cpap Loss Of Aeration Atelectasis Preterm Neonate Respiratory Distress Syndrome

ClinConnect Summary

NPLUS is used to detect various artifacts that emerge due to air and fluid ratio in the lungs. The image results form a beam reflection and reverberation of echoes on tissues. The most important artifacts display A-lines, B-lines and the pleural line with the lung sliding. A-lines (horizontal, hyperechogenic long line reverberation artefacts of the pleura) are a sign of aeration. B-lines (vertical, hyperechoic ring-down artefacts arising from the pleural line) indicate fluid in the interstitial space. The pleural line is a smooth, hyperechoic line. Breathing or ventilation causes a movement...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • All preterm infants (\<33 weeks gestational age) from their 2nd week of life, receiving respiratory support via NCPAP
  • expected to stay on NCPAP for the following 5 days at the NICU, Royal Hospital for Women, Randwick, Sydney
  • provided written informed consent obtained from parents.
  • Exclusion Criteria:
  • Neonates with previous abdominal surgery
  • Major congenital anomalies.
  • \>33+0 weeks
  • Less than 1 week of age
  • Invasive ventilation
  • Bilevel or Multilevel non-invasive ventilation
  • Not expected respiratory support via CPAP for the following 5 days.

Trial Officials

Tim Schindler BMedSc MBBS FRACP PhD

Principal Investigator

Senior Staff Specialist, Royal Hospital for Women, Conjoint Associate Professor, University of New South Wales

About Royal Hospital For Women

The Royal Hospital for Women is a leading healthcare institution dedicated to advancing women's health through innovative clinical research and trials. With a commitment to excellence in patient care and a focus on evidence-based practices, the hospital collaborates with multidisciplinary teams to conduct groundbreaking studies across various aspects of women's health, including obstetrics, gynecology, and reproductive medicine. By fostering a collaborative environment, the Royal Hospital for Women aims to enhance treatment options, improve clinical outcomes, and contribute to the global body of knowledge in women's health.

Locations

Sydney, New South Wales, Australia

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported