To Evaluate Mucosal and Systematic Immune Response to Acute Respiratory Tract Infections of South African Children

Launched by DESMOND TUTU TB CENTRE · Mar 28, 2025

Keywords

ClinConnect Summary

This clinical trial is looking into how respiratory infections, like COVID-19, affect children in South Africa. Researchers want to understand how these infections show up in kids, which symptoms to look for, and which children are at higher risk of getting very sick. They will also study the immune response in kids—specifically, how immune cells in their saliva and blood react to these infections. Additionally, the study will assess how these respiratory infections impact children's lung function and their overall quality of life, as well as their families.

Children aged 0 to 13 years who are experiencing acute respiratory infections and visiting Tygerberg Hospital in Cape Town may be eligible to participate in this study. Participants will undergo tests to help researchers gather important information about their health and immune responses. This study aims to recruit at least 250 children, and by joining, families can contribute to understanding and improving care for respiratory infections in children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Children aged 0-13 years with acute respiratory tract infections presenting to Tygerberg Hospital (TBH) in Cape Town, South Africa, for routine care
• Exclusion Criteria:
• • Admitted for \< 72 hours