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Search / Trial NCT06902194

To Evaluate Mucosal and Systematic Immune Response to Acute Respiratory Tract Infections of South African Children

Launched by DESMOND TUTU TB CENTRE · Mar 28, 2025

Trial Information

Current as of April 29, 2025

Recruiting

Keywords

Mucosal Immunity Mucosal Immunology Respiratory Tract Infections Saliva

ClinConnect Summary

This clinical trial is looking into how respiratory infections, like COVID-19, affect children in South Africa. Researchers want to understand how these infections show up in kids, which symptoms to look for, and which children are at higher risk of getting very sick. They will also study the immune response in kids—specifically, how immune cells in their saliva and blood react to these infections. Additionally, the study will assess how these respiratory infections impact children's lung function and their overall quality of life, as well as their families.

Children aged 0 to 13 years who are experiencing acute respiratory infections and visiting Tygerberg Hospital in Cape Town may be eligible to participate in this study. Participants will undergo tests to help researchers gather important information about their health and immune responses. This study aims to recruit at least 250 children, and by joining, families can contribute to understanding and improving care for respiratory infections in children.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • - Children aged 0-13 years with acute respiratory tract infections presenting to Tygerberg Hospital (TBH) in Cape Town, South Africa, for routine care
  • Exclusion Criteria:
  • Admitted for \< 72 hours

About Desmond Tutu Tb Centre

The Desmond Tutu TB Centre, based at Stellenbosch University in South Africa, is a leading research organization dedicated to advancing the understanding and treatment of tuberculosis (TB). Founded in honor of Archbishop Desmond Tutu, the Centre focuses on innovative clinical trials and epidemiological studies to develop effective interventions against TB and improve patient outcomes. With a commitment to scientific excellence and community engagement, the Centre collaborates with local and international partners to address the global TB crisis and contribute to the eradication of this infectious disease.

Locations

Cape Town, Western Cape, South Africa

Cape Town, Western Cape, South Africa

Patients applied

0 patients applied

Trial Officials

Marieke van der Zalm, PhD

Principal Investigator

Desmond Tutu TB Centre

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported