Dairy Choline Bioavailability

Launched by UNIVERSITY OF WISCONSIN, MADISON · Mar 24, 2025

Keywords

ClinConnect Summary

This clinical trial, called "Dairy Choline Bioavailability," is exploring whether dairy products, specifically a type of whey protein, are as good a source of choline as eggs for post-menopausal women. Choline is an important nutrient that our bodies need for various functions, and the researchers want to understand how our bodies use it. Participants will be asked to drink a chocolate-flavored beverage that contains either whey protein phospholipid concentrate (WPPC) or whole egg powder to see how effective each source is for choline absorption.

To be eligible for this study, women aged 51 to 70 who are post-menopausal can participate, provided they are not allergic to dairy or eggs and have maintained a stable body weight for the last six months. Participants will need to complete health surveys, keep a food diary for four days, and provide samples of blood, urine, and stool at the start and after 10 days of drinking the study beverages. It's important for participants to be in good health, free from certain medical conditions, and willing to avoid rigorous exercise during the study. This research could help us understand more about the best sources of choline for women in this age group.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Ages between 51 and 70
• • Is currently post-menopausal (Post-menopausal is a term used to describe the time in a woman's life after she has gone through menopause. This usually happens between the ages of 45 and 55. Menopause is when a woman's menstrual periods stop permanently (at least 12 months))
• • Not allergic to the intervention foods and allergens that are related to the production of intervention foods (e.g. dairy products, egg, fish, peanut, shellfish, soy, tree nuts, wheat, crustaceans, gluten, mollusks, mustard, sesame seeds.)
• • Had stable body weight (± 5%) for the past 6 months
• • Free from cancer
• • Did not have weight loss surgery, colon surgery
• • Do not have chronic kidney diseases
• • Do not have malabsorption towards fat and dairy products
• • Willing to complete health surveys
• • Willing to complete two 4-day food records
• • Willing to consume the chocolate-flavored intervention beverages
• • Willing to provide blood, urine, fecal samples at baseline and after 10 days of intervention
• Exclusion Criteria:
• • On weight loss/weight gain diets
• • Diagnosed with fat malabsorption
• • Undergoing weight loss surgery
• • Diagnosed with chronic kidney diseases
• • Allergic to the intervention foods and allergens that are related to the production of intervention foods (e.g. dairy products, egg, fish, peanut, shellfish, soy, tree nuts, wheat, crustaceans, gluten, mollusks, mustard, sesame seeds.)
• • Regularly using antibiotics or probiotics or prebiotics
• • Regularly using Orlistat or Cetilistat
• • Regularly using laxatives
• • Undergoing hormone replacement therapy, or receiving hormones in any forms
• • Unable to avoid strenuous exercise during the study (\>4 h intense exercise per day)