Nightmare Deconstruction and Reprocessing Pilot
Launched by UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES · Mar 24, 2025
Trial Information
Current as of June 06, 2025
Completed
Keywords
ClinConnect Summary
The current study is testing NDR, a three-stage treatment that integrates exposure, reprocessing, and rescripting of nightmare images to alleviate nightmare and insomnia severity. Study aims are to test NDR's plausibility and tolerability and to test the methodologic feasibility of collecting daily HRV, EDA, and actigraphy data via the E4 wristband as well as peripheral blood samples for assay at three time points. Participants are active duty military or veterans (N = 30) ages 18 to 64 with posttraumatic nightmares and insomnia. Participants undergo 8 NDR treatment visits over 8 weeks and ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Active duty servicemembers and DEERS-eligible veterans
- • DDNSI score ≥ 10
- • PSQI score \> 5
- Exclusion Criteria:
- • Current imminent risk of suicide
- • Psychotic or bipolar disorders
- • Untreated moderate to severe sleep apnea/hypopnea, circadian rhythm disorders, or narcolepsy
- • Current use of prazosin for nightmares
- • Self-reported alcohol use \> 4x/ week and \> 3 drinks per occasion
- • Concurrent evidence-based or experimental treatment directly targeting nightmares, insomnia, or PTSD
- • Initiation of or change in psychotropic medications for PTSD, nightmares, insomnia, depression, or anxiety in the past 8 weeks
- • Inability to recall nightmare content
- • Inability to comply with requirement to wear E4 wristband and upload daily
About Uniformed Services University Of The Health Sciences
The Uniformed Services University of the Health Sciences (USU) is a premier academic institution dedicated to advancing the health and well-being of military personnel and their families through innovative research, education, and clinical training. As a key sponsor of clinical trials, USU focuses on addressing unique health challenges faced by service members and veterans, fostering collaboration among military and civilian researchers. By integrating cutting-edge scientific inquiry with practical applications, USU aims to improve healthcare outcomes and enhance the readiness of the armed forces, while contributing to the broader medical community through the dissemination of impactful findings.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
San Diego, California, United States
Bethesda, Maryland, United States
Patients applied
Trial Officials
Patricia T Spangler, PhD
Principal Investigator
Uniformed Services University and Henry M Jackson Foundation
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported