Exploratory Clinical Study on Fasting in Psoriasis and Psoriatic Arthritis (RiseFast)

Launched by CHARITE UNIVERSITY, BERLIN, GERMANY · Mar 25, 2025

Keywords

ClinConnect Summary

The RiseFast study is exploring how fasting and a plant-based diet might help people with psoriasis and psoriatic arthritis. Researchers want to see how these changes in eating habits affect not just the skin and joint symptoms, but also the gut health of participants. The study includes a week of fasting followed by 11 weeks of eating a plant-based diet. The goal is to find ways to improve symptoms and quality of life for participants, while also gaining insights into how these dietary changes could be a low-cost treatment option with few side effects.

To participate in the RiseFast study, you need to be at least 18 years old and have active plaque psoriasis or psoriatic arthritis. You should also have been on a stable treatment for at least 12 weeks before joining the study. However, pregnant or breastfeeding individuals, those with certain health conditions, or anyone who has been following a vegan diet or fasting recently won't be eligible. If you join, you can expect to engage in assessments about your condition and health throughout the study, helping researchers understand the potential benefits of fasting and a plant-based diet for managing psoriasis and psoriatic arthritis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Active plaque psoriasis (PASI ≥3) or Psoriatic Arthritis fulfilling the Classification Criteria for Psoriatic Arthritis (CASPAR) and not meeting MDA criteria
• • on stable baseline psoriatic treatment for 12 weeks before enrollment
• • ≥ 18 years old
• Exclusion Criteria:
• • Pregnancy or breastfeeding
• • underweight (BMI ≤18,5)
• • eating disorder in the last 5 years
• • severe internal diseases (e.g. renal insufficiency with creatinine \> 2mg/dl)
• • current practice of vegan diet or fasting within the past 6 months
• • use of antibiotics within the past 3 months