RNA Assays for Endometriosis Detection and Diagnosis

Launched by WREN LABORATORIES LLC · Mar 25, 2025

Keywords

ClinConnect Summary

Endometriosis is a common disease that affects up to 10% of women of reproductive age. Diagnosis, however, is typically delayed (up to 12 years) and is typically made after surgery. A key unmet need therefore is an accurate, non-invasive biomarker that can be used to detect the disease early.

We hypothesize that endometriosis-related circulating gene expression can be identified using transcriptomic and bioinformatics approaches and used to construct an accurate diagnostic tool for this condition.

The primary objective is to develop a gene signature that detects endometriosis. The hypothe...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • For the endometriosis cohort
• • a history of infertility more than 1 year
• • age 20-35 years
• • normal liver and kidney function, without gynaecological and other systemic disease
• • Inclusion criteria for controls include normo-ovulatory history, aged between 20-35 years, who exhibit normal liver and kidney function, and do not have any systemic diseases including autoimmune disease.
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• Exclusion Criteria:
• • For the endometriosis cohort
• • polycystic ovary syndrome, hyperprolactinemia
• • severe cardiovascular system, liver, kidney, and hematopoietic system disease
• • autoimmune disease
• • uterine fibroids, endometritis, non-vegetative ovarian cysts, ovarian malignancies, and internal genital tuberculosis
• • Exclusion criteria for the controls includes gynaecological malignancies and genital tuberculosis.
• • -