Clinical Trials for Acute Leukemia of Ambiguous Lineage

Find clinical trials for acute leukemia of ambiguous lineage. Discover research opportunities and treatment options in your area.

13 Active Trials Found

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Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

NCT ID: NCT06317662

This clinical trial is studying whether adding two specific anti-cancer treatments, called venetoclax and blinatumomab, to the usual chemotherapy can help infants with a type of leukemia known as a...

Recruiting

Phase: PHASE2 Type: interventional Locations: Philadelphia, Pennsylvania, United States, Dallas, Texas, United States +52 more

Venetoclax Combined With Azactidine in the Treatment of ALAL

NCT ID: NCT05901974

This clinical trial is studying a new treatment for patients diagnosed with Acute Leukemia of Ambiguous Lineage (ALAL), a type of blood cancer that is often difficult to treat. The researchers want...

Recruiting

Phase: PHASE2 Type: interventional Locations: Suzhou, , China

First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia

NCT ID: NCT04067336

This clinical trial is testing a new medication called ziftomenib in patients with acute myeloid leukemia (AML) who have not responded to other treatments or whose cancer has returned. The trial is...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Rochester, Minnesota, United States +64 more

Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage

NCT ID: NCT04440267

This clinical trial is investigating a new treatment approach for patients with a type of cancer called acute leukemia of ambiguous lineage. The study will enroll 50 participants who are 14 years o...

Recruiting

Phase: PHASE2 Type: interventional Locations: Tianjin, Tianjin, China

Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid Cancer

NCT ID: NCT07046078

This clinical trial is studying a new treatment approach for adults aged 60 and older who have been recently diagnosed with a high-risk form of acute myeloid leukemia (AML) or other similar serious...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

Randomization for the Identification of Best Treatment Intensity for Less Fit Adults With Acute Myeloid Leukemia and Myeloid Neoplasms

NCT ID: NCT07094750

This clinical trial is looking at the best level of chemotherapy treatment for adults who have a type of blood cancer called acute myeloid leukemia (AML) or related conditions, but who may not be s...

Not yet recruiting

Phase: NA Type: interventional Locations: Seattle, Washington, United States

Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases

NCT ID: NCT06013423

This clinical trial is investigating a new treatment approach for patients with serious blood cancers, like acute leukemia and certain lymphomas. The study is testing how effective a transplant usi...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seattle, Washington, United States

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

NCT ID: NCT06177067

This clinical trial is studying a new combination of treatments for young patients with a type of blood cancer called acute myeloid leukemia (AML) or acute leukemia of ambiguous lineage (ALAL). Spe...

Recruiting

Phase: PHASE1 Type: interventional Locations: Memphis, Tennessee, United States, Cincinnati, Ohio, United States +4 more

Venetoclax Basket Trial for High Risk Hematologic Malignancies

NCT ID: NCT05292664

The Venetoclax Basket Trial is a research study aimed at testing the safety and effectiveness of a medication called venetoclax in combination with chemotherapy for young patients facing serious bl...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Aurora, Colorado, United States +3 more

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

NCT ID: NCT03779854

This clinical trial is looking at a new way to help prevent a condition called chronic graft-versus-host disease (GVHD) in children and young adults with certain types of blood cancers, such as leu...

Recruiting

Phase: PHASE2 Type: interventional Locations: Cleveland, Ohio, United States, Iowa City, Iowa, United States +10 more

Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial

NCT ID: NCT06355583

The MAST Trial is a clinical study designed to see if a treatment called intestinal microbiota transplantation (IMT) can help improve the gut health of patients with certain blood cancers, like leu...

Recruiting

Phase: PHASE2 Type: interventional Locations: London, , United Kingdom, Manchester, , United Kingdom +6 more

Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

NCT ID: NCT06575296

This clinical trial is exploring a new treatment called revumenib for patients with acute leukemia who have recently received a stem cell transplant. Revumenib is designed to block a specific prote...

Recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States

A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

NCT ID: NCT04065399

This clinical trial is studying a new medication called revumenib for patients with various types of acute leukemia, including those with specific genetic changes. The trial has two phases: the fir...

Recruiting

Phase: PHASE1 Type: interventional Locations: Columbus, Ohio, United States, Philadelphia, Pennsylvania, United States +62 more

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