Clinical Trials for Central Nervous System Lymphoma

Find clinical trials for central nervous system lymphoma. Discover research opportunities and treatment options in your area.

19 Active Trials Found

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LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma

NCT ID: NCT03684980

This clinical trial is investigating a drug called Voraxaze (glucarpidase) to see how it works when combined with the standard treatments, methotrexate and rituximab, for patients with Central Nerv...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Birmingham, Alabama, United States, New York, New York, United States +10 more

Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma

NCT ID: NCT05625594

This clinical trial is investigating a new treatment for patients with primary central nervous system lymphoma, a type of cancer that affects the brain and spinal cord. The study focuses on using a...

Recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States

Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies

NCT ID: NCT05011045

This clinical trial is studying how whole brain radiation therapy affects memory and thinking skills in patients with certain blood cancers, such as lymphoma, leukemia, and myeloma. The goal is to ...

Recruiting

Type: observational Locations: Houston, Texas, United States

Q702 for the Treatment of Patients With Hematologic Malignancies

NCT ID: NCT06712810

This clinical trial is studying a new medication called Q702 to see how safe it is and how well it works for people with certain types of blood cancers, known as hematologic malignancies. These can...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Scottsdale, Arizona, United States, Rochester, Minnesota, United States

Loncastuximab Tesirine and Rituximab Following Stereotactic Radiosurgery (SRS) in Patients With Primary and Secondary Central Nervous System Lymphomas (Lonca-R After SRS in CNSL)

NCT ID: NCT06607549

This clinical trial, called Lonca-R After SRS in CNSL, is testing two medications, loncastuximab tesirine and rituximab, to see if they are safe and effective for patients with central nervous syst...

Recruiting

Phase: PHASE1 Type: interventional Locations: Salt Lake City, Utah, United States

Pharmacogenomics Effects on High-Dose Methotrexate Clearance in Patients With Diffuse Large B-Cell Lymphoma

NCT ID: NCT06031194

This clinical trial is looking at how genetics can affect the way high doses of a chemotherapy drug called methotrexate are cleared from the body in patients with diffuse large B-cell lymphoma (DLB...

Recruiting

Type: observational Locations: Columbus, Ohio, United States

DALY II USA/ MB-CART2019.1 for DLBCL

NCT ID: NCT04792489

The DALY II USA trial is studying a new treatment called zamtocabtagene autoleucel (MB-CART2019.1) for patients with certain types of aggressive lymphoma, specifically those whose cancer has not re...

Recruiting

Phase: PHASE2 Type: interventional Locations: Rochester, Minnesota, United States, Ann Arbor, Michigan, United States +24 more

Orelabrutinib Combined With Pemetrexed For Relapsed/Refractory Central Nervous System Lymphoma

NCT ID: NCT05209620

This clinical trial is studying the combination of two medications, orelabrutinib and pemetrexed, to see how well they work together in treating patients with relapsed or refractory central nervous...

Recruiting

Phase: PHASE2 Type: interventional Locations: Zhengzhou, Henan, China

CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

NCT ID: NCT04186520

This clinical trial is investigating a new treatment using specially modified immune cells, called CAR-20/19-T cells, to help patients with certain types of blood cancers, such as Non-Hodgkin Lymph...

Recruiting

Phase: PHASE1 Type: interventional Locations: Milwaukee, Wisconsin, United States

Acalabrutinib in CNSL

NCT ID: NCT04906902

This clinical trial is investigating a medication called Acalabrutinib for patients with recurrent or treatment-resistant central nervous system lymphoma (CNSL), a type of cancer that affects the b...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States +2 more

Human CD19-CD22 Targeted T Cells Injection for Refractory/Relapsed Central Nervous System Leukemia/Lymphoma Patients

NCT ID: NCT05651178

This clinical trial is studying a new treatment for patients with Central Nervous System (CNS) Lymphoma, specifically those who have not responded to previous therapies or whose cancer has come bac...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Nanchang, Jiangxi, China

Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphoma/Leukemia (PMBCL/CNS-BCL).

NCT ID: NCT06213636

This clinical trial is exploring a new treatment using advanced CAR T cells, which are specially modified immune cells, to help patients with certain types of difficult-to-treat cancers, particular...

Recruiting

Phase: PHASE1 Type: interventional Locations: Manama, , Bahrain, Shanghai, , China +1 more

Long-term Follow-up Study of Patients Receiving CAR-T Cells

NCT ID: NCT03375619

This clinical trial is a long-term follow-up study for patients who have received CAR-T cell therapy as part of earlier clinical trials at the Medical College of Wisconsin and Froedtert Hospital. C...

Recruiting

Type: observational Locations: Milwaukee, Wisconsin, United States

Selinexor in Combination With MTX+Ritu to Treat R/R CNSL

NCT ID: NCT05698147

This clinical trial is investigating a new treatment approach for patients with a type of brain cancer called primary central nervous system lymphoma (PCNSL). The study is testing a combination of ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Fuzhou, Fujian, China, Hefei, Anhui, China +3 more

Secondary Central Nervous System Lymphoma Registry - Charité

NCT ID: NCT05114330

The Secondary Central Nervous System Lymphoma Registry - Charité is a clinical trial designed to gather information about how patients with secondary central nervous system lymphoma (SCNSL) are tre...

Recruiting

Type: observational Locations: Berlin, , Germany

Decitabine and Anti-PD-1 in R/R DLBCL

NCT ID: NCT05816746

This clinical trial is studying the effects of a combination treatment using low-dose Decitabine and an anti-PD-1 medication for patients with relapsed or refractory diffuse large B cell lymphoma, ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Beijing, Beijing, China

Lenalidomide Maintenance Treatment in Patients With Primary Central Nervous System Lymphoma

NCT ID: NCT05260619

This clinical trial is studying the use of a medication called lenalidomide as a maintenance treatment for patients with primary central nervous system lymphoma (PCNSL) who cannot receive certain s...

Recruiting

Phase: PHASE2 Type: interventional Locations: Seongnam Si, Please Select, Korea, Republic Of

Intermediate Dose of IV MTX as CNS Prophylaxis for High Risk DLBCL

NCT ID: NCT05054426

This clinical trial is studying the use of an intermediate dose of intravenous methotrexate (IV MTX) to help prevent the central nervous system (CNS) from being affected in patients with high-risk ...

Recruiting

Phase: PHASE3 Type: interventional Locations: Beijing, Beijing, China

Rituximab,Zanubrutinib in Combination With Lenalidomide, Followed by Zanubrutinib or Lenalidomide Maintenance in Patients With Primary or Secondary CNS Lymphoma

NCT ID: NCT04938297

This clinical trial is studying a combination of three medications—rituximab, zanubrutinib, and lenalidomide—to see how well they work together in treating patients with central nervous system lymp...

Recruiting

Phase: PHASE2 Type: interventional Locations: Zhengzhou, Henan, China

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