A Study of Sigvotatug Vedotin in Advanced Solid Tumors

NCT ID: NCT04389632

This clinical trial is studying a new drug called sigvotatug vedotin (SGN-B6A) to see how safe it is and if it can help treat various advanced solid tumors, such as lung cancer, breast cancer, and ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States +184 more

A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

NCT ID: NCT06628310

This clinical trial is studying a new treatment approach for adults with advanced stomach cancer that cannot be surgically removed or has spread to other parts of the body. The researchers want to ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Duarte, California, United States, Hattiesburg, Mississippi, United States +14 more

A Phase Ib Trial Evaluating the Safety and Activity of Neoadjuvant Combination of Tislelizumab Plus FLOT for Resectable Esophagogastric Adenocarcinoma

NCT ID: NCT07059299

This clinical trial is testing a new treatment approach for patients with certain types of cancer in the esophagus or stomach that can be removed by surgery. The study is looking at whether combini...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Leipzig, , Germany

A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer

NCT ID: NCT06523374

This clinical trial is focused on understanding the experiences of patients with Barrett's Esophagus, a condition that can increase the risk of developing esophageal cancer. The study aims to colle...

Recruiting

Phase: NA Type: interventional Locations: Copenhagen, , Denmark, Gent, , Belgium +8 more

Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma

NCT ID: NCT07059611

This clinical trial is testing a new approach to treating certain types of stomach and esophagus cancers (called gastroesophageal adenocarcinomas) before surgery. Researchers want to see if injecti...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Philadelphia, Pennsylvania, United States

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

NCT ID: NCT06324357

The Beamion BCGC-1 trial is looking at a new treatment option for adults with specific types of advanced HER2-positive cancer, including metastatic breast cancer and certain gastric cancers that ha...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Seattle, Washington, United States +64 more

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

NCT ID: NCT06732388

This clinical trial is studying a new approach to help prevent esophageal cancer in patients who have a condition called Barrett's esophagus, which puts them at higher risk for this type of cancer....

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Cleveland, Ohio, United States, Cleveland, Ohio, United States +5 more

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

NCT ID: NCT06071845

This clinical trial is studying a new, easy-to-use tool called the Cytosponge to help detect Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) in patients. Barrett's esophagus is a condi...

Recruiting

Phase: NA Type: interventional Locations: Chicago, Illinois, United States, Scottsdale, Arizona, United States +3 more

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

NCT ID: NCT06005493

This clinical trial is investigating a new treatment called AZD5863 for adults with advanced cancer, specifically focusing on types like gastric cancer, gastro-esophageal junction cancer, pancreati...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States, Dundee, , United Kingdom +23 more

A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer

NCT ID: NCT06623396

This clinical trial is studying a new type of treatment called mesothelin-targeted CAR T-cell therapy for people with certain types of esophagogastric cancer, which includes esophageal adenocarcino...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, Basking Ridge, New Jersey, United States +5 more

Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer

NCT ID: NCT02366819

This clinical trial is exploring a new way to give chemotherapy to patients with advanced stomach or esophageal cancer. The study focuses on using genetic testing to help doctors figure out the bes...

Recruiting

Phase: PHASE4 Type: interventional Locations: Chicago, Illinois, United States, Evanston, Illinois, United States +1 more

ProofPrincip IntraTu TCells SinglDoseImmunCheckpoinInhib Gastro-Esophage Adenocarcinoma w/ARID1a Mu

NCT ID: NCT06824363

This clinical trial is designed to test a new treatment approach for patients with specific types of stomach and esophageal cancers that have a mutation in a gene called ARID1A. The study aims to s...

Not yet recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Orange, California, United States

Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of BL-M05D1 in Subjects With Solid Tumors

NCT ID: NCT07021066

This clinical trial is studying a new treatment called BL-M05D1 for patients with certain types of advanced solid tumors, including gastric, pancreatic, esophageal, and mucinous ovarian cancers. Th...

Not yet recruiting

Phase: PHASE1 Type: interventional

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

NCT ID: NCT03961945

This clinical trial is looking at a new device called a sponge capsule that can help find Barrett's Esophagus and related conditions like esophageal adenocarcinoma, which is a type of cancer. The t...

Recruiting

Phase: NA Type: interventional Locations: Rochester, Minnesota, United States, Jacksonville, Florida, United States +7 more

Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

NCT ID: NCT06340711

This clinical trial is studying a new combination treatment for patients with advanced or metastatic esophageal and gastric cancer, specifically using a research drug called Suratadenoturev (OBP-30...

Recruiting

Phase: PHASE2 Type: interventional Locations: New York, New York, United States

Obeticholic Acid for Prevention in Barrett's Esophagus

NCT ID: NCT04939051

This clinical trial is exploring the use of a medication called obeticholic acid to see if it can help prevent the progression of Barrett's esophagus, a condition where the lining of the esophagus ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Cleveland, Ohio, United States, Cleveland, Ohio, United States +10 more

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

NCT ID: NCT05902988

This clinical trial is studying a new treatment called VLS-1488 for people with advanced cancers, including types like ovarian, lung, breast, and colorectal cancer. The goal is to find out how safe...

Recruiting

Phase: PHASE1 Type: interventional Locations: Los Angeles, California, United States, Ann Arbor, Michigan, United States +12 more

Propranolol With Standard Chemoradiation for Esophageal Adenocarcinoma

NCT ID: NCT04682158

This clinical trial is studying how well a medication called propranolol works when given alongside standard treatments for esophageal adenocarcinoma, which is a type of cancer in the esophagus. Re...

Recruiting

Phase: PHASE2 Type: interventional Locations: Buffalo, New York, United States

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

NCT ID: NCT05480384

This clinical trial is studying the combination of two treatments, trastuzumab deruxtecan (also known as Enhertu) and nivolumab, for patients who have completed their initial cancer treatment for c...

Recruiting

Phase: PHASE2 Type: interventional Locations: Providence, Rhode Island, United States, New York, New York, United States

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

NCT ID: NCT06687603

This clinical trial is focused on finding a new way to detect Barrett's esophagus, a condition where the lining of the esophagus is damaged due to acid reflux. The trial is specifically looking at ...

Recruiting

Phase: NA Type: interventional Locations: Cleveland, Ohio, United States, Baltimore, Maryland, United States +3 more

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Clinical Trials for Esophageal Adenocarcinoma

39 Active Trials Found

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

A Phase Ib Trial Evaluating the Safety and Activity of Neoadjuvant Combination of Tislelizumab Plus FLOT for Resectable Esophagogastric Adenocarcinoma

A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer

Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer

Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer

ProofPrincip IntraTu TCells SinglDoseImmunCheckpoinInhib Gastro-Esophage Adenocarcinoma w/ARID1a Mu

Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of BL-M05D1 in Subjects With Solid Tumors

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

Obeticholic Acid for Prevention in Barrett's Esophagus

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

Propranolol With Standard Chemoradiation for Esophageal Adenocarcinoma

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

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