Clinical Trials for Gastroesophageal Junction Adenocarcinoma

Find clinical trials for gastroesophageal junction adenocarcinoma. Discover research opportunities and treatment options in your area.

53 Active Trials Found

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A Study of Sigvotatug Vedotin in Advanced Solid Tumors

NCT ID: NCT04389632

This clinical trial is studying a new drug called sigvotatug vedotin (SGN-B6A) to see how safe it is and if it can help treat various advanced solid tumors, such as lung cancer, breast cancer, and ...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States +184 more

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

NCT ID: NCT06131840

This clinical trial is investigating an experimental drug called PF-08046050, which is designed to treat adults with advanced solid tumors, including types of cancer like colorectal, stomach, pancr...

Recruiting

Phase: PHASE1 Type: interventional Locations: Rochester, Minnesota, United States, Boston, Massachusetts, United States +49 more

A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors

NCT ID: NCT06157892

This clinical trial is looking at a new treatment option for people with advanced solid tumors, specifically breast and gastric cancers that have a certain protein called HER2. HER2 can make these ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Tampa, Florida, United States, Saint Louis, Missouri, United States +155 more

A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

NCT ID: NCT06628310

This clinical trial is studying a new treatment approach for adults with advanced stomach cancer that cannot be surgically removed or has spread to other parts of the body. The researchers want to ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Duarte, California, United States, Hattiesburg, Mississippi, United States +15 more

A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

NCT ID: NCT07043400

This clinical trial is studying a cancer treatment called tislelizumab for adults with advanced stomach cancer or cancer where the stomach meets the esophagus. The goal is to compare two ways of gi...

Not yet recruiting

Phase: PHASE3 Type: interventional Locations: Chicago, Illinois, United States, Nashville, Tennessee, United States +96 more

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

NCT ID: NCT06764875

This clinical trial is studying a new treatment for patients with HER2-positive gastric cancer, which is a type of stomach cancer that has a specific protein (HER2) on its cells. The treatment bein...

Recruiting

Phase: PHASE3 Type: interventional Locations: Barcelona, , Spain, Dallas, Texas, United States +237 more

Hypofractionated Radiotherapy Combined With Immunochemotherapy for Conversion Treatment of Gastroesophageal Junction Adenocarcinoma

NCT ID: NCT07072351

This clinical trial is studying a new treatment approach for people with a type of cancer located where the esophagus meets the stomach, called gastroesophageal junction adenocarcinoma. The researc...

Not yet recruiting

Phase: PHASE1 Type: interventional Locations: Chengdu, Sichuan, China

Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma

NCT ID: NCT07059611

This clinical trial is testing a new approach to treating certain types of stomach and esophagus cancers (called gastroesophageal adenocarcinomas) before surgery. Researchers want to see if injecti...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Philadelphia, Pennsylvania, United States

A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer

NCT ID: NCT06038578

This clinical trial is studying a new treatment called TRK-950, which will be given together with two existing medications, ramucirumab and paclitaxel, to see if this combination is effective for t...

Recruiting

Phase: PHASE2 Type: interventional Locations: Duarte, California, United States, Kashiwa, Chiba, Japan +30 more

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

NCT ID: NCT06324357

The Beamion BCGC-1 trial is looking at a new treatment option for adults with specific types of advanced HER2-positive cancer, including metastatic breast cancer and certain gastric cancers that ha...

Recruiting

Phase: PHASE1 Type: interventional Locations: Boston, Massachusetts, United States, Seattle, Washington, United States +64 more

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

NCT ID: NCT03175224

The APL-101 clinical trial is exploring a new treatment for patients with advanced lung cancer, specifically those with certain genetic changes called c-Met Exon 14 skipping mutations or MET amplif...

Recruiting

Phase: PHASE2 Type: interventional Locations: Rochester, Minnesota, United States, Madison, Wisconsin, United States +114 more

A Phase 1b/2 Clinical Trial Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AUR103 Calcium in Patients With HER2-positive Advanced Gastric/Gastroesophageal Junction Adenocarcinoma

NCT ID: NCT07040059

This clinical trial is studying a new treatment called AUR103 Calcium for people with advanced stomach cancer or cancer near where the stomach meets the esophagus, specifically when the cancer test...

Recruiting

Phase: PHASE1 Type: interventional Locations: Ahmedabad, Gujarat, India, Kolkata, West Bengal, India +6 more

NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer

NCT ID: NCT04615013

This clinical trial is studying a new treatment approach for patients with esophageal adenocarcinoma, a type of cancer that affects the esophagus. The treatment combines a drug called NBTXR3, which...

Recruiting

Phase: PHASE1 Type: interventional Locations: Houston, Texas, United States

Relationship Between Perioperative Treatment Efficacy and The Tumor Microenvironment for Locally Advanced Resectable Gastric Cancer.

NCT ID: NCT04850729

This clinical trial is studying how effective drug treatments before and after surgery are for patients with locally advanced gastric cancer, specifically focusing on the tumor microenvironment (TM...

Recruiting

Type: observational Locations: Guangzhou, Guangdong, China

Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

NCT ID: NCT07001748

This clinical trial is exploring a new way to treat patients with gastric cancer that has spread to the abdominal cavity. The researchers want to find out if giving a chemotherapy drug called pacli...

Not yet recruiting

Phase: PHASE2 Type: interventional

Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study

NCT ID: NCT05753306

The ROBO-CHIP study is a clinical trial that is exploring a new treatment approach for patients with gastric cancer that has spread to the lining of the abdomen, known as peritoneal metastasis. Thi...

Recruiting

Phase: PHASE2 Type: interventional Locations: Rochester, Minnesota, United States

Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

NCT ID: NCT06340711

This clinical trial is studying a new combination treatment for patients with advanced or metastatic esophageal and gastric cancer, specifically using a research drug called Suratadenoturev (OBP-30...

Recruiting

Phase: PHASE2 Type: interventional Locations: New York, New York, United States

A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroesophageal Junction Cancers

NCT ID: NCT06243757

This clinical trial is comparing two types of surgical procedures for patients with gastric cancer or cancer at the gastroesophageal junction. The study aims to find out whether a minimally invasiv...

Recruiting

Type: observational Locations: New York, New York, United States, Harrison, New York, United States +6 more

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

NCT ID: NCT06265285

This clinical trial is exploring whether giving a cancer treatment called nivolumab at home is just as safe and effective as receiving it in a clinic. By allowing patients to receive treatment in t...

Recruiting

Phase: PHASE2 Type: interventional Locations: Jacksonville, Florida, United States

Total Neoadjuvant FLOT Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Cancer

NCT ID: NCT06028737

This clinical trial is looking at the best way to treat patients with locally advanced gastric cancer, which is a type of stomach cancer that has not yet spread to distant parts of the body. The tr...

Recruiting

Phase: PHASE2 Type: interventional Locations: Kyiv, , Ukraine, Vilnius, , Lithuania

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