Clinical Trials for Head and Neck Squamous Cell Carcinoma

Find clinical trials for head and neck squamous cell carcinoma. Discover research opportunities and treatment options in your area.

182 Active Trials Found

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A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

NCT ID: NCT05877599

This clinical trial is studying a new treatment called NT-175 for adults with advanced solid tumors, which are types of cancer that cannot be removed by surgery. Specifically, this trial focuses on...

Recruiting

Phase: PHASE1 Type: interventional Locations: Duarte, California, United States, Boston, Massachusetts, United States +22 more

PD-L1 t-haNK, N-803 IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

NCT ID: NCT06239220

This clinical trial is exploring a new treatment combination for patients with advanced head and neck cancer that has come back or spread to other parts of the body. The study is testing three ther...

Recruiting

Phase: PHASE2 Type: interventional Locations: Boston, Massachusetts, United States, Boston, Massachusetts, United States

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

NCT ID: NCT06525220

This clinical trial is evaluating a new treatment approach for patients with head and neck cancer that has spread or come back after initial treatment. It compares two options: a combination of two...

Recruiting

Phase: PHASE3 Type: interventional Locations: Houston, Texas, United States, Durham, North Carolina, United States +139 more

PET-imaging of Two Vartumabs in Patients With Solid Tumors

NCT ID: NCT06645808

The VARTUTRACE clinical trial is studying two new imaging agents that can help doctors see and understand solid tumors, which are types of cancer that form in various organs. This study is particul...

Recruiting

Phase: EARLY_PHASE1 Type: interventional Locations: Groningen, , Netherlands

Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC

NCT ID: NCT06855212

This clinical trial is studying the effectiveness and safety of two medications, cemiplimab and cetuximab, given before surgery for patients with head and neck squamous cell carcinoma (HNSCC). The ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Tampa, Florida, United States

Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial

NCT ID: NCT06995508

The MACRO trial is a study looking at how well olanzapine, a medication often used for mental health conditions, can help manage loss of appetite (anorexia) in patients with head and neck cancer wh...

Not yet recruiting

Phase: PHASE2 Type: interventional Locations: Buffalo, New York, United States

Observational Basket Trial to Collect Tissue to Train and Validate a Live Tumor Diagnostic Platform

NCT ID: NCT05520099

This clinical trial is studying a new diagnostic tool called the Cybrid live tumor diagnostic platform, which aims to help doctors better understand and predict how solid tumors, like certain cance...

Recruiting

Type: observational Locations: Orlando, Florida, United States, Madison, Wisconsin, United States +9 more

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

NCT ID: NCT06992427

This clinical trial, called the HOPE trial, is studying whether a medication called gabapentin can help reduce pain from mouth sores (known as oral mucositis) in patients receiving chemotherapy and...

Not yet recruiting

Phase: PHASE3 Type: interventional

SYS6002 Plus JMT101 and Enlonstobart Injection as First-Line Treatment for HNSCC

NCT ID: NCT06989671

This clinical trial is testing a new combination of treatments for patients with advanced head and neck squamous cell carcinoma (HNSCC), which is a type of cancer that can affect areas like the mou...

Not yet recruiting

Phase: PHASE2 Type: interventional

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and Other Solid Tumors, Receiving Intravenous (IV) Infusion of Azirkitug (ABBV-514) Alone or in Combination With Budigalimab or Bevacizumab

NCT ID: NCT05005403

This clinical trial is studying two investigational drugs, ABBV-514 and Budigalimab, to see how they affect adults with advanced Non-Small Cell Lung Cancer (NSCLC) or Head and Neck Squamous Cell Ca...

Recruiting

Phase: PHASE1 Type: interventional Locations: Fullerton, California, United States, Miami, Florida, United States +45 more

A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer

NCT ID: NCT05544136

This clinical trial is investigating a new treatment plan for people with certain types of head and neck cancer. The goal is to see if using less radiation and chemotherapy, followed by surgery to ...

Recruiting

Phase: PHASE2 Type: interventional Locations: New York, New York, United States, Middletown, New Jersey, United States +6 more

A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer

NCT ID: NCT04722523

This clinical trial is investigating a new treatment approach for people with head and neck cancer. The aim is to see if combining standard chemotherapy with two immunotherapy drugs, cemiplimab (th...

Recruiting

Phase: PHASE1 Type: interventional Locations: New York, New York, United States, New York, New York, United States +9 more

Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma.

NCT ID: NCT06727565

This clinical trial is studying new combination therapies for patients with head and neck squamous cell carcinoma, a type of cancer that can occur in areas like the mouth and throat. The main goal ...

Recruiting

Phase: PHASE2 Type: interventional Locations: Saint Louis, Missouri, United States, Houston, Texas, United States +23 more

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

NCT ID: NCT06147037

This clinical trial is studying a new treatment called [225Ac]-FPI-2068 for adults with certain advanced cancers, including metastatic colorectal cancer, head and neck cancer, non-small cell lung c...

Recruiting

Phase: PHASE1 Type: interventional Locations: Chicago, Illinois, United States, Edmonton, Alberta, Canada +15 more

Adjuvant Immunotherapy After Salvage Surgery in Head and Neck Squamous Cell Carcinoma

NCT ID: NCT03406247

This clinical trial is studying the effects of a new type of treatment called immunotherapy for patients who have undergone salvage surgery for head and neck squamous cell carcinoma (HNSCC). The go...

Recruiting

Phase: PHASE2 Type: interventional Locations: Villejuif, Val De Marne, France

Study of CHS-114 in Participants With Advanced Solid Tumors

NCT ID: NCT05635643

This clinical trial is studying a new treatment called CHS-114, which is a type of medication known as a monoclonal antibody. It is specifically designed for patients with advanced solid tumors, in...

Recruiting

Phase: PHASE1 Type: interventional Locations: Ann Arbor, Michigan, United States, Saint Louis, Missouri, United States +12 more

A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors

NCT ID: NCT06437522

This clinical trial is studying a combination treatment of two medications, BL-B01D1 and a PD-1 monoclonal antibody, for patients with recurrent or metastatic head and neck squamous cell carcinoma,...

Recruiting

Phase: PHASE2 Type: interventional Locations: Shanghai, Shanghai, China

Pilot Study of MPB-2043 Enhanced MRI for Nodal Staging in Head and Neck Squamous Cell Carcinomas

NCT ID: NCT06540443

This clinical trial is looking at a new imaging agent called MPB-2043, which is designed to improve MRI scans for patients with head and neck squamous cell carcinoma, a type of cancer that can spre...

Recruiting

Phase: PHASE1 Type: interventional Locations: Taipei, , Taiwan

A Study of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors

NCT ID: NCT06006169

This clinical trial is studying two experimental treatments, called BL-B01D1 and SI-B003, to see how effective they are in treating patients with recurrent or metastatic head and neck squamous cell...

Recruiting

Phase: PHASE2 Type: interventional Locations: Shanghai, Shanghai, China

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

NCT ID: NCT06163534

This clinical trial is focused on studying patients with Head and Neck Squamous Cell Carcinoma (HNSCC), a type of cancer affecting the head and neck area. Researchers will collect and analyze tissu...

Recruiting

Type: observational Locations: Columbus, Ohio, United States, Philadelphia, Pennsylvania, United States +15 more

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